Source:http://linkedlifedata.com/resource/pubmed/id/17303116
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
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pubmed:dateCreated |
2007-3-2
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pubmed:abstractText |
The dopamine D3 receptor is primarily localized within the mesocorticolimbic system, and may therefore have potential as a pharmacotherapeutic target for the treatment of drug dependence. Studies have shown that the selective dopamine D3 receptor antagonist SB-277011A reduces a variety of dependence-related behavioral effects of cocaine, alcohol and heroin. A previous study examining SB-277011A on nicotine self-administration using relatively low doses of the antagonist and a low response requirement for nicotine found no effect on drug-taking behavior per se, whereas reinstatement of nicotine-seeking was reduced. The purpose of the present study was to further examine the effects of higher doses of SB-277011A on nicotine self-administration in rats under a progressive-ratio (PR) schedule, which imposes relatively high response requirements for nicotine. Rats were trained to respond under a PR schedule of either nicotine or food reinforcement. Once responding was stable, SB-277011A (3-56 mg/kg) or vehicle was administered i.p. 1 h prior to the operant session. The highest dose tested significantly decreased the mean number of reinforcers and mean response rates in the nicotine self-administration group, but had no effect on either the mean number of reinforcers or response rate in the food group. In a separate set of experiments, the effects of SB-277011A on locomotor activity were measured. At the dose that significantly decreased nicotine self-administration, total distance traveled was also significantly decreased, suggesting that the effect on operant responding at the high dose of SB-277011A is at a threshold for motor effects and may not be directly mediated by an action at dopamine D3 receptors.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotine,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotinic Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D3,
http://linkedlifedata.com/resource/pubmed/chemical/SB 277011,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydroisoquinolines
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
559
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-9
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:17303116-Animals,
pubmed-meshheading:17303116-Behavior, Animal,
pubmed-meshheading:17303116-Conditioning, Operant,
pubmed-meshheading:17303116-Dopamine Antagonists,
pubmed-meshheading:17303116-Dose-Response Relationship, Drug,
pubmed-meshheading:17303116-Eating,
pubmed-meshheading:17303116-Infusions, Intravenous,
pubmed-meshheading:17303116-Male,
pubmed-meshheading:17303116-Motor Activity,
pubmed-meshheading:17303116-Nicotine,
pubmed-meshheading:17303116-Nicotinic Agonists,
pubmed-meshheading:17303116-Nitriles,
pubmed-meshheading:17303116-Rats,
pubmed-meshheading:17303116-Rats, Long-Evans,
pubmed-meshheading:17303116-Receptors, Dopamine D3,
pubmed-meshheading:17303116-Reinforcement Schedule,
pubmed-meshheading:17303116-Reward,
pubmed-meshheading:17303116-Self Administration,
pubmed-meshheading:17303116-Tetrahydroisoquinolines,
pubmed-meshheading:17303116-Tobacco Use Disorder
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pubmed:year |
2007
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pubmed:articleTitle |
Effects of the selective dopamine D3 receptor antagonist SB-277011A on the reinforcing effects of nicotine as measured by a progressive-ratio schedule in rats.
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pubmed:affiliation |
Minneapolis Medical Research Foundation, 914 South 8th Street, Minneapolis, MN 55404, USA.
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pubmed:publicationType |
Journal Article
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