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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-2-15
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pubmed:abstractText |
Growth hormone receptor-deficient (GHRKO) mice are long-lived and have reduced insulin-like growth factor (IGF)-1 and insulin levels and enhanced insulin sensitivity thus resembling the phenotype of animals subjected to calorie restriction (CR). In contrast to its effects in normal mice, CR does not improve insulin sensitivity or increase longevity in GHRKO males. In an attempt to identify mechanisms underlying this differential response to CR, effects of CR on the expression of insulin-related genes were compared in GHRKO and normal mice. In addition to changes detected in both genotypes, and responses unique to GHRKO mice, the levels of Akt2 and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC1alpha) were increased and levels of phosphorylated c-Jun N-terminal kinase (JNK)1 were reduced in response to CR only in normal mice. These changes may be related to mechanisms of improving insulin sensitivity and life expectancy.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AMP-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Akt2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/FoxO3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Foxo1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Ppargc1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/protein kinase C lambda
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1079-5006
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
18-26
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17301033-AMP-Activated Protein Kinases,
pubmed-meshheading:17301033-Aging,
pubmed-meshheading:17301033-Animals,
pubmed-meshheading:17301033-Caloric Restriction,
pubmed-meshheading:17301033-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17301033-Female,
pubmed-meshheading:17301033-Forkhead Transcription Factors,
pubmed-meshheading:17301033-Gene Expression Regulation, Developmental,
pubmed-meshheading:17301033-Growth Hormone,
pubmed-meshheading:17301033-Immunoblotting,
pubmed-meshheading:17301033-Insulin Resistance,
pubmed-meshheading:17301033-Isoenzymes,
pubmed-meshheading:17301033-Male,
pubmed-meshheading:17301033-Mice,
pubmed-meshheading:17301033-Mice, Knockout,
pubmed-meshheading:17301033-Mitogen-Activated Protein Kinase 8,
pubmed-meshheading:17301033-Mitogen-Activated Protein Kinase 9,
pubmed-meshheading:17301033-Multienzyme Complexes,
pubmed-meshheading:17301033-Muscle, Skeletal,
pubmed-meshheading:17301033-Phosphorylation,
pubmed-meshheading:17301033-Protein Kinase C,
pubmed-meshheading:17301033-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17301033-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17301033-RNA, Messenger,
pubmed-meshheading:17301033-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17301033-Trans-Activators,
pubmed-meshheading:17301033-Zebrafish Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle.
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pubmed:affiliation |
Departments of Internal Medicine, Southern Illinois University, School of Medicine, Springfield, USA. kalregai@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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