Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-2-15
pubmed:abstractText
Notch signaling is essential for myogenesis and the regenerative potential of skeletal muscle; however, its regulation in human muscle is yet to be fully characterized. Increased expression of Notch3, Jagged1, Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells. Furthermore, significantly lower expressions of Notch1, Jagged1, Numb, and Delta-like 1 were evident in muscle biopsies from older men (60-75 years old) compared to muscle from younger men (18-25 years old). Importantly, with supervised resistance exercise training, expression of Notch1 and Hes6 genes were increased and Delta-like 1 and Numb expression were decreased. The differences in Notch expression between the age groups were no longer evident following training. These results provide further evidence to support the role of Notch in the impaired regulation of muscle mass with age and suggest that some of the benefits provided by resistance training may be mediated through the Notch signaling pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix..., http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DLK1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins, http://linkedlifedata.com/resource/pubmed/chemical/HES1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/HES6 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/NOTCH1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/NOTCH3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Numb protein, human, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Notch1, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Serrate proteins
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1079-5006
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9-17
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:17301032-Adolescent, pubmed-meshheading:17301032-Adult, pubmed-meshheading:17301032-Aged, pubmed-meshheading:17301032-Aging, pubmed-meshheading:17301032-Basic Helix-Loop-Helix Transcription Factors, pubmed-meshheading:17301032-Biopsy, pubmed-meshheading:17301032-Blotting, Western, pubmed-meshheading:17301032-Calcium-Binding Proteins, pubmed-meshheading:17301032-Cell Differentiation, pubmed-meshheading:17301032-Cells, Cultured, pubmed-meshheading:17301032-Drosophila Proteins, pubmed-meshheading:17301032-Female, pubmed-meshheading:17301032-Gene Expression Regulation, Developmental, pubmed-meshheading:17301032-Homeodomain Proteins, pubmed-meshheading:17301032-Humans, pubmed-meshheading:17301032-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:17301032-Male, pubmed-meshheading:17301032-Membrane Proteins, pubmed-meshheading:17301032-Middle Aged, pubmed-meshheading:17301032-Muscle, Skeletal, pubmed-meshheading:17301032-Nerve Tissue Proteins, pubmed-meshheading:17301032-Physical Exertion, pubmed-meshheading:17301032-RNA, Messenger, pubmed-meshheading:17301032-Receptor, Notch1, pubmed-meshheading:17301032-Receptors, Notch, pubmed-meshheading:17301032-Regeneration, pubmed-meshheading:17301032-Repressor Proteins, pubmed-meshheading:17301032-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:17301032-Signal Transduction
pubmed:year
2007
pubmed:articleTitle
Impaired expression of Notch signaling genes in aged human skeletal muscle.
pubmed:affiliation
School of Exercise and Nutrition Sciences, Deakin University, Victoria, Australia.
pubmed:publicationType
Journal Article