Linked Life Data

17300668

Source:http://linkedlifedata.com/resource/pubmed/id/17300668

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-2-15
pubmed:abstractText
In contrast to the clear oncogenic role of cyclins D1 and D2, cyclin D3 is suggested to have a role in the initiation and/or maintenance of differentiation in a lineage-associated manner in addition to its basic role in proliferation. Recently, it has been reported that in cyclin D3-deficient mice, normal expansion of T lymphocytes is impaired because of maturation arrest at the double-negative thymocyte stage, suggesting a crucial role for cyclin D3 in early T-cell development. Therefore, cyclin D3 expression was examined in 36 human precursor T-lymphoblastic leukemia/lymphomas (T-LBLL), a neoplastic counterpart of T cells at the early developmental stages of differentiation. Using a standard panel of differentiation markers, all T-LBLL were categorized into four stages according to differentiation: progenitor, double-negative, double-positive, and single-positive stages. Cyclin D3 expression was initiated at the boundary between double-negative and double-positive stages, and was sustained in the single-positive stage. T-cell receptor was expressed simultaneously with cyclin D3, whereas CD79a expression was specific in the double-negative stage, and thus it was inversely correlated with that of cyclin D3. Taken together with the crucial and non-redundant role in T-cell development in mice, this molecule is suggested to play an important role in human T-cell development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1320-5463
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17300668-Antigens, CD79, pubmed-meshheading:17300668-Cell Differentiation, pubmed-meshheading:17300668-Cell Proliferation, pubmed-meshheading:17300668-Cell Transformation, Neoplastic, pubmed-meshheading:17300668-Child, pubmed-meshheading:17300668-Child, Preschool, pubmed-meshheading:17300668-Cyclin D3, pubmed-meshheading:17300668-Cyclins, pubmed-meshheading:17300668-Disease Progression, pubmed-meshheading:17300668-Gene Expression Regulation, Neoplastic, pubmed-meshheading:17300668-Humans, pubmed-meshheading:17300668-Infant, pubmed-meshheading:17300668-Leukemia, Lymphoid, pubmed-meshheading:17300668-Male, pubmed-meshheading:17300668-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:17300668-Receptors, Antigen, T-Cell, pubmed-meshheading:17300668-Thymus Gland
pubmed:year
2007
pubmed:articleTitle
Development-dependent expression of cyclin D3 in precursor T-cell lymphoblastic leukemia/lymphoma.
pubmed:affiliation
Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't