Source:http://linkedlifedata.com/resource/pubmed/id/17299526
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2007-3-8
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| pubmed:abstractText |
Concentrations of N-terminal pro brain natriuretic peptide (NT-proBNP) increase in patients with heart failure and other cardiovascular (CV) diseases and are strong prognostic markers. In patients with end-stage renal disease (ESRD) in hemodialysis (HD), levels of NT-proBNP are almost always raised. In ESRD patients undergoing HD, we aimed at (i) identifying the factors that affect levels of NT-proBNP, (ii) determining the effect of HD on NT-proBNP, and (iii) determining the prognostic impact of NT-proBNP. A total of 109 patients underwent physical examination, electrocardiogram, and echocardiography. Serum NT-proBNP was measured before and after HD (Elecsys 2010). NT-proBNP levels were markedly elevated (pre-HD 4079 pg/ml, post-HD 2759 pg/ml, P<0.001). There was a strong inverse correlation between NT-proBNP and left ventricular ejection fraction (LVEF) (P=0.043), 24-h urine production (P=0.006), and K(t)/V (efficacy of dialysis) (P=0.016) and a positive correlation with left ventricular hypertrophy (LVH) (P=0.014). Patients with higher concentrations, both pre- and post-HD had an increased mortality rate compared to those with lower concentrations (P=0.007, P=0.002). We found age (P=0.009) and NT-proBNP (pre-HD P=0.007, post-HD P=0.001) predictive of death. Our findings demonstrate that CV disease in terms of LVH and reduced LVEF in addition to 24-h urine production and K(t)/V determine NT-proBNP levels. Post-HD levels of NT-proBNP were lower than pre-HD levels; both predictive of mortality.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Natriuretic Peptide, Brain,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/pro-brain natriuretic peptide (1-76)
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0085-2538
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
71
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
548-54
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| pubmed:meshHeading |
pubmed-meshheading:17299526-Adult,
pubmed-meshheading:17299526-Aged,
pubmed-meshheading:17299526-Aged, 80 and over,
pubmed-meshheading:17299526-Biological Markers,
pubmed-meshheading:17299526-Cardiovascular Diseases,
pubmed-meshheading:17299526-Female,
pubmed-meshheading:17299526-Humans,
pubmed-meshheading:17299526-Kidney Failure, Chronic,
pubmed-meshheading:17299526-Male,
pubmed-meshheading:17299526-Middle Aged,
pubmed-meshheading:17299526-Natriuretic Peptide, Brain,
pubmed-meshheading:17299526-Peptide Fragments,
pubmed-meshheading:17299526-Predictive Value of Tests,
pubmed-meshheading:17299526-Prognosis,
pubmed-meshheading:17299526-Regression Analysis,
pubmed-meshheading:17299526-Renal Dialysis,
pubmed-meshheading:17299526-Risk Factors,
pubmed-meshheading:17299526-Stroke Volume,
pubmed-meshheading:17299526-Ventricular Dysfunction, Left
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| pubmed:year |
2007
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| pubmed:articleTitle |
N-terminal pro brain natriuretic peptide predicts mortality in patients with end-stage renal disease in hemodialysis.
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| pubmed:affiliation |
Department of Cardiology and Endocrinology, Frederiksberg University Hospital, Copenhagen, Denmark. lhm@dadlnet.dk
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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