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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-3-30
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pubmed:abstractText |
The immunopharmacological profile of novel biocompatible water-soluble interleukin-2 (IL-2)-conjugated 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer immunosuppressive agents was established. MPC-co-n- butyl methacrylate (BMA)-co-p-nitrophenylcarbonyloxyethyl methacrylate (NPMA) (PMBN) was prepared as a backbone for these novel agents. PMBN contained MPC as a biocompatible unit, BMA as a hydrophobic domain in water, and NPMA as an immobilizable unit with IL-2. This research showed that proliferation of cell lines with high-affinity IL-2 receptors derived from T cell malignancies were suppressed by the PMBN conjugated with IL-2 (PMBN-IL2 conjugate) incorporating paclitaxel (PTX) and cyclosporin A at lower concentrations than used conventionally. PMBN-IL2 conjugates incorporating PTX also inhibited the proliferation of responder cells in a human mixed lymphocyte culture at a lower concentration than unconjugated drug. However, PMBN-IL2 conjugates incorporating FK506 inhibited proliferation no more than FK506 alone. The PMBN-IL2 conjugate with PTX may therefore be useful for selectively eliminating activated lymphocytes that hyperproduce high-affinity IL-2 receptors. As an entirely human 'immunotoxin analogue' it may not be associated with the dose-limiting toxicity and immunogenicity of conventional immunotoxins.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Methacrylates,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus,
http://linkedlifedata.com/resource/pubmed/chemical/poly(2-methacryloyloxyethyl...
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pubmed:status |
MEDLINE
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pubmed:issn |
0014-312X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2007 S. Karger AG, Basel.
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-10
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17299267-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:17299267-Biocompatible Materials,
pubmed-meshheading:17299267-Cell Division,
pubmed-meshheading:17299267-Cell Line, Tumor,
pubmed-meshheading:17299267-Cyclosporine,
pubmed-meshheading:17299267-Drug Delivery Systems,
pubmed-meshheading:17299267-Humans,
pubmed-meshheading:17299267-Hydrophobic and Hydrophilic Interactions,
pubmed-meshheading:17299267-Immunosuppressive Agents,
pubmed-meshheading:17299267-Interleukin-2,
pubmed-meshheading:17299267-Lymphocyte Activation,
pubmed-meshheading:17299267-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:17299267-Methacrylates,
pubmed-meshheading:17299267-Paclitaxel,
pubmed-meshheading:17299267-Polyethylene Glycols,
pubmed-meshheading:17299267-Solubility,
pubmed-meshheading:17299267-T-Lymphocytes,
pubmed-meshheading:17299267-Tacrolimus
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pubmed:year |
2007
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pubmed:articleTitle |
Novel immunosuppressant agents targeting activated lymphocytes by biocompatible MPC polymer conjugated with interleukin-2.
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pubmed:affiliation |
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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