Linked Life Data

17298854

Source:http://linkedlifedata.com/resource/pubmed/id/17298854

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-5-9
pubmed:abstractText
There have been no target molecules that have enabled us to diagnose lung cancer with high sensitivity and specificity even in its early clinical stages. A molecule termed novel oncogene with kinase-domain (NOK) was recently reported as a receptor protein tyrosine kinase that is expressed in some cancer cell lines and causes the transformation and progressive proliferation of normal cells. Therefore, NOK could be a possible candidate for a diagnostic marker for human cancers. We examined here, the degree of NOK mRNA expression in lung cancer tissues and compared it to that in non-cancerous tissues. More than 60% of non-cancerous samples (8/13) showed undetectable levels of mRNA. In contrast, NOK mRNA was detected in 97.6% (40/41) of lung cancer tissues, resulting in a sensitivity of 80.5% and a specificity of 92.3% that was estimated using the cutoff obtained from receiver operating characteristic curve analysis. Further, NOK mRNA expression was found to be elevated in 92.3% (12/13) of cancerous tissues when paired cancerous and non-cancerous tissues from identical patients were compared. There were no obvious correlations between clinicopathological factors and NOK mRNA expression; however, NOK mRNA was highly expressed even at the early clinical stages of the cancer. These results suggest that NOK mRNA might be a new tool to support the diagnosis of lung cancers, irrespective of the clinical stages.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0169-5002
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
337-40
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers.
pubmed:affiliation
Department of Clinical Laboratory Medicine, Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-Ku, Sapporo 060-8543, Japan.
pubmed:publicationType
Journal Article, Multicenter Study