Source:http://linkedlifedata.com/resource/pubmed/id/17298710
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2007-2-14
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| pubmed:abstractText |
n-3 PUFA have shown potential anti-obesity and insulin-sensitising properties. However, the mechanisms involved are not clearly established. The aim of the present study was to assess the effects of EPA administration, one of the n-3 PUFA, on body-weight gain and adiposity in rats fed on a standard or a high-fat (cafeteria) diet. The actions on white adipose tissue lipolysis, apoptosis and on several genes related to obesity and insulin resistance were also studied. Control and cafeteria-induced overweight male Wistar rats were assigned into two subgroups, one of them daily received EPA ethyl ester (1 g/kg) for 5 weeks by oral administration. The high-fat diet induced a very significant increase in both body weight and fat mass. Rats fed with the cafeteria diet and orally treated with EPA showed a marginally lower body-weight gain (P = 0.09), a decrease in food intake (P < 0.01) and an increase in leptin production (P < 0.05). EPA administration reduced retroperitoneal adipose tissue weight (P < 0.05) which could be secondary to the inhibition of the adipogenic transcription factor PPARgamma gene expression (P < 0.001), and also to the increase in apoptosis (P < 0.05) found in rats fed with a control diet. TNFalpha gene expression was significantly increased (P < 0.05) by the cafeteria diet, while EPA treatment was able to prevent (P < 0.01) the rise in this inflammatory cytokine. Adiposity-corrected adiponectin plasma levels were increased by EPA. These actions on both TNFalpha and adiponectin could explain the beneficial effects of EPA on insulin resistance induced by the cafeteria diet.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adiponectin,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Eicosapentaenoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0007-1145
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
97
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
389-98
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:17298710-Adiponectin,
pubmed-meshheading:17298710-Adipose Tissue,
pubmed-meshheading:17298710-Animals,
pubmed-meshheading:17298710-Apoptosis,
pubmed-meshheading:17298710-Dietary Fats,
pubmed-meshheading:17298710-Dietary Supplements,
pubmed-meshheading:17298710-Eating,
pubmed-meshheading:17298710-Eicosapentaenoic Acid,
pubmed-meshheading:17298710-Gene Expression,
pubmed-meshheading:17298710-Insulin,
pubmed-meshheading:17298710-Insulin Resistance,
pubmed-meshheading:17298710-Leptin,
pubmed-meshheading:17298710-Lipolysis,
pubmed-meshheading:17298710-Male,
pubmed-meshheading:17298710-PPAR gamma,
pubmed-meshheading:17298710-RNA, Messenger,
pubmed-meshheading:17298710-Rats,
pubmed-meshheading:17298710-Rats, Wistar,
pubmed-meshheading:17298710-Tumor Necrosis Factor-alpha,
pubmed-meshheading:17298710-Weight Gain
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| pubmed:year |
2007
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| pubmed:articleTitle |
Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-alpha.
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| pubmed:affiliation |
Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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