Source:http://linkedlifedata.com/resource/pubmed/id/17297432
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2007-2-13
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pubmed:abstractText |
Trimethoprim-Sulfomethoxazole (TMP-SMX) related hepatotoxicity and associated severe systemic reaction are not frequent and documented only in case reports. We report a case of a 30-year-old man, who underwent a 15-day therapy with TMP-SMX for urinary tract infection and two weeks later developed acute cholestatic hepatitis, fever and a skin rash followed by severe systemic reaction. He was admitted in Intensive Care unit and with supportive therapy and prednisolone administration, he showed subsequent improvement over a period of few days. He had fully recovered months later. All tests for other causes of liver disease were negative and his liver biopsy showed evidence of drug-induced hepatic injury.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1665-2681
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
63-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17297432-Adult,
pubmed-meshheading:17297432-Biopsy,
pubmed-meshheading:17297432-Cholestasis,
pubmed-meshheading:17297432-Diagnosis, Differential,
pubmed-meshheading:17297432-Drug Combinations,
pubmed-meshheading:17297432-Drug-Induced Liver Injury,
pubmed-meshheading:17297432-Humans,
pubmed-meshheading:17297432-Male,
pubmed-meshheading:17297432-Severity of Illness Index,
pubmed-meshheading:17297432-Sulfamethizole,
pubmed-meshheading:17297432-Tomography, X-Ray Computed,
pubmed-meshheading:17297432-Trimethoprim,
pubmed-meshheading:17297432-Urinary Tract Infections
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pubmed:articleTitle |
Cholestatic hepatitis with severe systemic reactions induced by trimethoprim-sulfamethoxazole.
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pubmed:affiliation |
Gastroenterology and Hepatology Department, 424 Army Hospital, Thessaloniki, Greece.
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pubmed:publicationType |
Journal Article,
Case Reports
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