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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-2-13
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pubmed:abstractText |
Cataplexy is one of the most pathognomonic symptoms in narcolepsy. This study was designed to investigate the frequency of the HLA-DQB1 allele and cerebrospinal fluid (CSF) hypocretin levels in Korean narcoleptics with cataplexy as compared with those who do not have cataplexy. Seventy-two narcoleptics were selected based on polysomnography and multiple sleep latency test as well as their history and clinical symptoms at Sleep Disorders Clinic. The patients were divided into a narcolepsy with cataplexy group (n=56) and a narcolepsy without cataplexy group (n=16). All patients were subjected to HLA typing to determine the frequency of DQB1 allele and to spinal tapping to measure the level of CSF hypocretin. In cataplexy-positive patients, as compared with cataplexy-negative patients, the frequency of HLA-DQB1*0602 was found to be significantly high (89.3% vs. 50.0%) (p=0.003). On the other hand, the frequency of HLA-DQB1*0601 was found to be significantly low (0% vs. 43.8%) (p<0.001). In 48 of 56 cataplexy-positive patients (85.7 %), hypocretin levels were decreased (<or=110 pg/mL). However, only 6 of 16 cataplexy-negative patients (37.5%) exhibited a decreased hyopcretin level (p<0.001). The high frequency of HLA-DQB1*0602, low frequency of HLA-DQB1*0601 and low hypocretin levels in cataplexy-positive groups suggest that cataplexy-positive narcolepsy might be an etiologically different disease entity from the cataplexy-negative.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-10458611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-10481909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-10615888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-10973318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-11055430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-11179016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-11222656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-11282968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-11869432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-12071546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-12374492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-14638887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-2196464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-2335305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-7677805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-8848983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-8871976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-9151385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-9419374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-9443450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-9456467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-9491897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-9822755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17297265-9989368
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1011-8934
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-31
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17297265-Adolescent,
pubmed-meshheading:17297265-Adult,
pubmed-meshheading:17297265-Aged,
pubmed-meshheading:17297265-Alleles,
pubmed-meshheading:17297265-Cataplexy,
pubmed-meshheading:17297265-Child,
pubmed-meshheading:17297265-Female,
pubmed-meshheading:17297265-HLA-DQ Antigens,
pubmed-meshheading:17297265-HLA-DQ beta-Chains,
pubmed-meshheading:17297265-Humans,
pubmed-meshheading:17297265-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:17297265-Male,
pubmed-meshheading:17297265-Middle Aged,
pubmed-meshheading:17297265-Narcolepsy,
pubmed-meshheading:17297265-Neuropeptides,
pubmed-meshheading:17297265-Sleep, REM
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pubmed:year |
2007
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pubmed:articleTitle |
HLA-DQB1 allele and hypocretin in Korean narcoleptics with cataplexy.
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pubmed:affiliation |
Department of Neuropsychiatry, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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