| pubmed-article:17297251 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17297251 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:17297251 | lifeskim:mentions | umls-concept:C1267092 | lld:lifeskim |
| pubmed-article:17297251 | lifeskim:mentions | umls-concept:C1704242 | lld:lifeskim |
| pubmed-article:17297251 | lifeskim:mentions | umls-concept:C0032433 | lld:lifeskim |
| pubmed-article:17297251 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17297251 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17297251 | pubmed:dateCreated | 2007-2-13 | lld:pubmed |
| pubmed-article:17297251 | pubmed:abstractText | This study was designed to investigate the effects of polyamines on mechanical contraction and voltage-dependent calcium current (VDCC) of guinea-pig gastric smooth muscle. Mechanical contraction and calcium channel current I(Ba) were recorded by isometric tension recording and whole-cell patch clamp technique. Spermine, spermidine and putrescine inhibited spontaneous contraction of the gastric smooth muscle in a concentration-dependent manner. Spermine (2 mM) reduced high K+ (50 mM)-induced contraction to 16+/-6.4% of the control (n=9), and significantly inhibited I(Ba) in a reversible manner (p<0.05; IC50=0.8 mM). Pre- and post-treatment of tissue with spermine (2-5 mM, n=10) also inhibited acetylcholine (10 microM)-induced phasic contraction to 5+/-6.4% of the control. Inhibitory effect of spermine on I(Ba) was observed at a wide range of test potentials of current/voltage (I/V) relationship (p<0.05), and steady-state activation of I(Ba) was shifted to the right by spermine (p<0.05). Spermidine and putrescine (1 mM each) also inhibited I(Ba) to 51+/-5.7% and 81+/-5.3% of the control, respectively. And putrescine (1 mM) inhibited I(Ba) at whole tested potentials (p<0.05) without significant change of kinetics (p<0.05). Finally, 5 mM putrescine also inhibited high K+-induced contraction to 53+/-7.1% of the control (n=4). These findings suggest that polyamines inhibit contractions of guinea-pig gastric smooth muscle via inhibition of VDCC. | lld:pubmed |
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| pubmed-article:17297251 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17297251 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297251 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17297251 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17297251 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17297251 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17297251 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17297251 | pubmed:issn | 1011-8934 | lld:pubmed |
| pubmed-article:17297251 | pubmed:author | pubmed-author:SimJae HoonJH | lld:pubmed |
| pubmed-article:17297251 | pubmed:author | pubmed-author:KimYoung... | lld:pubmed |
| pubmed-article:17297251 | pubmed:author | pubmed-author:KimKi WhanKW | lld:pubmed |
| pubmed-article:17297251 | pubmed:author | pubmed-author:KimYoung HoYH | lld:pubmed |
| pubmed-article:17297251 | pubmed:author | pubmed-author:LeeSang JinSJ | lld:pubmed |
| pubmed-article:17297251 | pubmed:author | pubmed-author:KimSeung... | lld:pubmed |
| pubmed-article:17297251 | pubmed:author | pubmed-author:XuWen-XieWX | lld:pubmed |
| pubmed-article:17297251 | pubmed:author | pubmed-author:KwonSeong-Chu... | lld:pubmed |
| pubmed-article:17297251 | pubmed:author | pubmed-author:ParkSeon-MeeS... | lld:pubmed |
| pubmed-article:17297251 | pubmed:author | pubmed-author:YounSei JinSJ | lld:pubmed |
| pubmed-article:17297251 | pubmed:author | pubmed-author:LeeSang-JeonS... | lld:pubmed |
| pubmed-article:17297251 | pubmed:author | pubmed-author:KimDong... | lld:pubmed |
| pubmed-article:17297251 | pubmed:author | pubmed-author:XingDe-GangDG | lld:pubmed |
| pubmed-article:17297251 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17297251 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:17297251 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17297251 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17297251 | pubmed:pagination | 48-56 | lld:pubmed |
| pubmed-article:17297251 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17297251 | pubmed:meshHeading | pubmed-meshheading:17297251... | lld:pubmed |
| pubmed-article:17297251 | pubmed:meshHeading | pubmed-meshheading:17297251... | lld:pubmed |
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| pubmed-article:17297251 | pubmed:meshHeading | pubmed-meshheading:17297251... | lld:pubmed |
| pubmed-article:17297251 | pubmed:meshHeading | pubmed-meshheading:17297251... | lld:pubmed |
| pubmed-article:17297251 | pubmed:meshHeading | pubmed-meshheading:17297251... | lld:pubmed |
| pubmed-article:17297251 | pubmed:meshHeading | pubmed-meshheading:17297251... | lld:pubmed |
| pubmed-article:17297251 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17297251 | pubmed:articleTitle | Effects of polyamines on contractility of guinea-pig gastric smooth muscle. | lld:pubmed |
| pubmed-article:17297251 | pubmed:affiliation | Department of Physiology, Chungbuk National University, College of Medicine, Cheongju, Korea. physiokyc@chungbuk.ac.kr | lld:pubmed |
| pubmed-article:17297251 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17297251 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17297251 | lld:pubmed |
