Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-4-19
pubmed:abstractText
During pulmonary mycobacterial infection, there is increased trafficking of dendritic cells from the lungs to the draining lymph nodes. We hypothesized that ongoing mycobacterial infection would modulate recruitment and activation of antigen-specific naive CD4+ T cells after airway antigen challenge. BALB/c mice were infected by aerosol with Mycobacterium bovis BCG. At peak bacterial burden in the lungs (4 to 6 weeks postinfection), carboxy-fluorescein diacetate succinimidyl ester-labeled naive ovalbumin-specific DO11.10 T cells were adoptively transferred into infected and uninfected mice. Recipient mice were challenged intranasally with soluble ovalbumin (OVA), and OVA-specific T-cell responses were measured in the lungs, draining mediastinal lymph nodes (MLN), and spleens. OVA challenge resulted in increased activation and proliferation of OVA-specific T cells in the draining MLN of both infected and uninfected mice. However, only BCG-infected mice had prominent OVA-specific T-cell activation, proliferation, and Th1 differentiation in the lungs. BCG infection caused greater distribution of airway OVA to pulmonary dendritic cells and enhanced presentation of OVA peptide by lung CD11c+ cells. Together, these data suggest that an existing pulmonary mycobacterial infection alters the phenotype of lung dendritic cells so that they can activate antigen-specific naive CD4+ T cells in the lungs in response to airway antigen challenge.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-10340945, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-10452998, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-10696070, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-10986412, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-11136820, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-11160010, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-11244029, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-11345807, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-11728873, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-11739490, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-11739518, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-12183593, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-12370257, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-12391188, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-12391242, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-12438442, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-12486107, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-12871638, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-12874299, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-12925677, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-14712275, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-14978073, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-14986673, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-15039373, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-15240712, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-15311275, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-15454922, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-15466619, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-16147980, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-16239580, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-16260739, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-16322591, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-16394002, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-16525420, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-16567390, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-16630021, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-16697232, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-16818746, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-2125367, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-2170533, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-7699319, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-7875199, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-9341763, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-9399965, http://linkedlifedata.com/resource/pubmed/commentcorrection/17296758-9463406
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2260-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...