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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-8-21
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pubmed:abstractText |
We have previously shown that the myocardium of patients with heart failure (HF) is insulin resistant. Chronic beta-adrenergic stimulation has been implicated in insulin resistance in cultured cardiomyocytes in vitro, where sustained noradrenaline stimulation inhibited insulin-modulated glucose uptake. As the failing heart is characterized by increased sympathetic drive, we hypothesized that there is a correlation between pre-synaptic sympathetic function and insulin sensitivity in the myocardium of patients with HF.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1619-7070
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1172-7
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pubmed:meshHeading |
pubmed-meshheading:17294189-Aged,
pubmed-meshheading:17294189-Coronary Angiography,
pubmed-meshheading:17294189-Coronary Artery Disease,
pubmed-meshheading:17294189-Fluorodeoxyglucose F18,
pubmed-meshheading:17294189-Glucose,
pubmed-meshheading:17294189-Heart,
pubmed-meshheading:17294189-Heart Failure,
pubmed-meshheading:17294189-Humans,
pubmed-meshheading:17294189-Insulin Resistance,
pubmed-meshheading:17294189-Magnetic Resonance Imaging,
pubmed-meshheading:17294189-Male,
pubmed-meshheading:17294189-Middle Aged,
pubmed-meshheading:17294189-Myocardium,
pubmed-meshheading:17294189-Myocytes, Cardiac,
pubmed-meshheading:17294189-Norepinephrine,
pubmed-meshheading:17294189-Positron-Emission Tomography,
pubmed-meshheading:17294189-Sensitivity and Specificity,
pubmed-meshheading:17294189-Ventricular Dysfunction, Left
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pubmed:year |
2007
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pubmed:articleTitle |
Myocardial pre-synaptic sympathetic function correlates with glucose uptake in the failing human heart.
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pubmed:affiliation |
Medical Research Council Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London, UK.
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pubmed:publicationType |
Journal Article
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