Linked Life Data

17293984

Source:http://linkedlifedata.com/resource/pubmed/id/17293984

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2007-2-12
pubmed:abstractText
The effects of pyrimethamine-sulphadoxine (PS), chloroquine plus chlorpheniramine, a H1 receptor antagonist that reverses chloroquine resistance in Plasmodium falciparum in vitro and in vivo (CQCP), and amodiaquine plus pyrimethamine-sulphadoxine (AQPS) on gametocyte production were evaluated in 157 children with acute, symptomatic, uncomplicated falciparum malaria who were treated with these drugs. PS was significantly less effective than CQCP or AQPS at clearing asexual parasitaemia or other symptoms of malaria. Gametocyte carriage on days 3, 7, and 14 were significantly higher in those treated with PS. The ratio of the density (per microl blood) of peripheral young gametocyte (PYG), that is, < or = stage III to peripheral mature gametocyte (PMG), that is, stage IV and V, an index of continuing generation of gametocytes, rose to 1 by day 7 of treatment in those treated with PS, but remained consistently below 1 in the other treatment groups. PYG-PMG density ratio increased significantly from day 0-14 in those treated with PS and CQCP (chi2 = 76, P = 0.000001 and chi2 = 42.2, P = 0.00001, respectively) but decreased significantly in those treated with AQPS (chi2 = 53.2, P = 0.000001). Both PS-sensitive and -resistant infections generated PYG (18 of 29 vs 13 of 20, chi2 = 0.04, P = 0.93) but PYG was present only in those with resistant response to CQCP. Combination of PS with amodiaquine (AQ), that is, (AQPS) resulted in less production of PYG, but in this setting, PYG was not indicative of response to AQPS. These data indicate that PS enhanced production or release of young gametocytes when used alone, but generated less young gametocytes when used in combination with AQ. PYG may be used as an indicator of response to CQCP but not PS or PS-based combination drugs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0074-0276
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
887-93
pubmed:meshHeading
pubmed-meshheading:17293984-Acute Disease, pubmed-meshheading:17293984-Amodiaquine, pubmed-meshheading:17293984-Animals, pubmed-meshheading:17293984-Antimalarials, pubmed-meshheading:17293984-Child, pubmed-meshheading:17293984-Child, Preschool, pubmed-meshheading:17293984-Chloroquine, pubmed-meshheading:17293984-Chlorpheniramine, pubmed-meshheading:17293984-Drug Combinations, pubmed-meshheading:17293984-Drug Therapy, Combination, pubmed-meshheading:17293984-Gametogenesis, pubmed-meshheading:17293984-Histamine H1 Antagonists, pubmed-meshheading:17293984-Humans, pubmed-meshheading:17293984-Malaria, Falciparum, pubmed-meshheading:17293984-Plasmodium falciparum, pubmed-meshheading:17293984-Pyrimethamine, pubmed-meshheading:17293984-Sulfadoxine, pubmed-meshheading:17293984-Time Factors, pubmed-meshheading:17293984-Treatment Outcome
pubmed:year
2006
pubmed:articleTitle
Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children.
pubmed:affiliation
Department of Pharmacology and Therapeutics, Postgraduate Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria. akinsowunmi@hotmail.com
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't