Source:http://linkedlifedata.com/resource/pubmed/id/17293876
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7130
|
| pubmed:dateCreated |
2007-2-22
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| pubmed:abstractText |
Type 2 diabetes mellitus results from the interaction of environmental factors with a combination of genetic variants, most of which were hitherto unknown. A systematic search for these variants was recently made possible by the development of high-density arrays that permit the genotyping of hundreds of thousands of polymorphisms. We tested 392,935 single-nucleotide polymorphisms in a French case-control cohort. Markers with the most significant difference in genotype frequencies between cases of type 2 diabetes and controls were fast-tracked for testing in a second cohort. This identified four loci containing variants that confer type 2 diabetes risk, in addition to confirming the known association with the TCF7L2 gene. These loci include a non-synonymous polymorphism in the zinc transporter SLC30A8, which is expressed exclusively in insulin-producing beta-cells, and two linkage disequilibrium blocks that contain genes potentially involved in beta-cell development or function (IDE-KIF11-HHEX and EXT2-ALX4). These associations explain a substantial portion of disease risk and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1476-4687
|
| pubmed:author |
pubmed-author:BaldingDavid JDJ,
pubmed-author:BalkauBeverleyB,
pubmed-author:BelisleAlexandreA,
pubmed-author:BoutinPhilippeP,
pubmed-author:CharpentierGuillaumeG,
pubmed-author:DinaChristianC,
pubmed-author:FroguelPhilippeP,
pubmed-author:HadjadjSamyS,
pubmed-author:HeudeBarbaraB,
pubmed-author:HudsonThomas JTJ,
pubmed-author:MeyreDavidD,
pubmed-author:MontpetitAlexandreA,
pubmed-author:PolychronakosConstantinC,
pubmed-author:PosnerBarry IBI,
pubmed-author:PrentkiMarcM,
pubmed-author:PshezhetskyAlexey VAV,
pubmed-author:RocheleauGhislainG,
pubmed-author:RungJohanJ,
pubmed-author:SerreDavidD,
pubmed-author:ShenLishuangL,
pubmed-author:SladekRobertR,
pubmed-author:VincentDanielD
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
22
|
| pubmed:volume |
445
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
881-5
|
| pubmed:meshHeading |
pubmed-meshheading:17293876-Case-Control Studies,
pubmed-meshheading:17293876-Cation Transport Proteins,
pubmed-meshheading:17293876-Chromosomes, Human, Pair 10,
pubmed-meshheading:17293876-Chromosomes, Human, Pair 8,
pubmed-meshheading:17293876-Diabetes Mellitus, Type 2,
pubmed-meshheading:17293876-France,
pubmed-meshheading:17293876-Genetic Predisposition to Disease,
pubmed-meshheading:17293876-Genome, Human,
pubmed-meshheading:17293876-Humans,
pubmed-meshheading:17293876-Linkage Disequilibrium
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
A genome-wide association study identifies novel risk loci for type 2 diabetes.
|
| pubmed:affiliation |
Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal H3A 1A4, Canada.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|