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pubmed-article:17292950pubmed:abstractTextOvarian cancer remains a leading cause of death in women and development of new therapies is essential. Second mitochondria derived activator of caspase (Smac) has been described to sensitize for apoptosis. We have explored the proapoptotic activity of a small molecule mimic of Smac/DIABLO on ovarian cancer cell lines (A2780 cells and its chemoresistant derivatives A2780/ADR and A2780/DDP), cancer cell lines and in primary ovarian cancer cells.lld:pubmed
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pubmed-article:17292950pubmed:articleTitleA small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells.lld:pubmed
pubmed-article:17292950pubmed:affiliationDepartment of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.lld:pubmed
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