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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-4-23
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pubmed:abstractText |
Ovarian cancer remains a leading cause of death in women and development of new therapies is essential. Second mitochondria derived activator of caspase (Smac) has been described to sensitize for apoptosis. We have explored the proapoptotic activity of a small molecule mimic of Smac/DIABLO on ovarian cancer cell lines (A2780 cells and its chemoresistant derivatives A2780/ADR and A2780/DDP), cancer cell lines and in primary ovarian cancer cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,6-bis(4,7-diaza-6-methyl-5-oxo-3-(...,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 9,
http://linkedlifedata.com/resource/pubmed/chemical/DIABLO protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Diynes,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, TNF-Related...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNF-Related Apoptosis-Inducing...,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF10A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/X-Linked Inhibitor of Apoptosis...,
http://linkedlifedata.com/resource/pubmed/chemical/XIAP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/mapatumumab
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0090-8258
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pubmed:author |
pubmed-author:Benedetti-PaniciPieluigiP,
pubmed-author:BiffoniMauroM,
pubmed-author:CognettiFrancescoF,
pubmed-author:FerrettiGianluigiG,
pubmed-author:HumphreysRobinR,
pubmed-author:MarianiGualtieroG,
pubmed-author:PasquiniLucaL,
pubmed-author:PeschleCesareC,
pubmed-author:PetronelliAlessiaA,
pubmed-author:PetrucciEleonoraE,
pubmed-author:RiccioniRobertaR,
pubmed-author:SaulleErnestinaE,
pubmed-author:ScambiaGiovanniG,
pubmed-author:TestaUgoU
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pubmed:issnType |
Print
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
481-92
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pubmed:dateRevised |
2008-5-14
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pubmed:meshHeading |
pubmed-meshheading:17292950-Antibodies, Monoclonal,
pubmed-meshheading:17292950-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:17292950-Apoptosis,
pubmed-meshheading:17292950-Apoptosis Regulatory Proteins,
pubmed-meshheading:17292950-Biomimetic Materials,
pubmed-meshheading:17292950-Caspase 3,
pubmed-meshheading:17292950-Caspase 9,
pubmed-meshheading:17292950-Cell Growth Processes,
pubmed-meshheading:17292950-Cell Line, Tumor,
pubmed-meshheading:17292950-Diynes,
pubmed-meshheading:17292950-Drug Synergism,
pubmed-meshheading:17292950-Enzyme Activation,
pubmed-meshheading:17292950-Female,
pubmed-meshheading:17292950-Humans,
pubmed-meshheading:17292950-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:17292950-Mitochondrial Proteins,
pubmed-meshheading:17292950-Ovarian Neoplasms,
pubmed-meshheading:17292950-Peptide Fragments,
pubmed-meshheading:17292950-Receptors, TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:17292950-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:17292950-TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:17292950-Tetrazoles,
pubmed-meshheading:17292950-X-Linked Inhibitor of Apoptosis Protein
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pubmed:year |
2007
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pubmed:articleTitle |
A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells.
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pubmed:affiliation |
Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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