| pubmed-article:17292937 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17292937 | lifeskim:mentions | umls-concept:C1623048 | lld:lifeskim |
| pubmed-article:17292937 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:17292937 | lifeskim:mentions | umls-concept:C0670896 | lld:lifeskim |
| pubmed-article:17292937 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:17292937 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:17292937 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:17292937 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:17292937 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:17292937 | lifeskim:mentions | umls-concept:C0599537 | lld:lifeskim |
| pubmed-article:17292937 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17292937 | pubmed:dateCreated | 2007-5-8 | lld:pubmed |
| pubmed-article:17292937 | pubmed:abstractText | We have previously shown that mutations of CD14 or TLR4 impair type I interferon (IFN) production and macrophage survival during infection with vesicular stomatitis virus (VSV). We now report that VSV glycoprotein G (gpG) is essential for the induction of a previously unrecognized CD14/TLR4-dependent response pathway in which the adapter TRAM has predominant importance, absent any need for MyD88 or Mal, and with only a partial requirement for TRIF. Downstream of TRAM, IRF7 activation leads to a type I IFN response. The pathway is utilized by myeloid dendritic cells (mDCs) and macrophages rather than plasmacytoid DCs. This new mode of TLR4 signal transduction, which does not stimulate NF-kappaB activation, reveals the importance of viral protein recognition by mDCs and shows that TLR4 can drive qualitatively different events within the cell in response to different ligands. | lld:pubmed |
| pubmed-article:17292937 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17292937 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17292937 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17292937 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17292937 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:17292937 | pubmed:author | pubmed-author:BeutlerBruceB | lld:pubmed |
| pubmed-article:17292937 | pubmed:author | pubmed-author:BahramSiamakS | lld:pubmed |
| pubmed-article:17292937 | pubmed:author | pubmed-author:OldstoneMicha... | lld:pubmed |
| pubmed-article:17292937 | pubmed:author | pubmed-author:KunzStefanS | lld:pubmed |
| pubmed-article:17292937 | pubmed:author | pubmed-author:JiangZhengfan... | lld:pubmed |
| pubmed-article:17292937 | pubmed:author | pubmed-author:GeorgelPhilip... | lld:pubmed |
| pubmed-article:17292937 | pubmed:author | pubmed-author:HoebeKasperK | lld:pubmed |
| pubmed-article:17292937 | pubmed:author | pubmed-author:JanssenEdithE | lld:pubmed |
| pubmed-article:17292937 | pubmed:author | pubmed-author:MolsJohannJ | lld:pubmed |
| pubmed-article:17292937 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17292937 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:17292937 | pubmed:volume | 362 | lld:pubmed |
| pubmed-article:17292937 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17292937 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17292937 | pubmed:pagination | 304-13 | lld:pubmed |
| pubmed-article:17292937 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:meshHeading | pubmed-meshheading:17292937... | lld:pubmed |
| pubmed-article:17292937 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17292937 | pubmed:articleTitle | Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. | lld:pubmed |
| pubmed-article:17292937 | pubmed:affiliation | Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA. philippe.georgel@hemato-ulp.u-strasbg.fr | lld:pubmed |
| pubmed-article:17292937 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17292937 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17292937 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:12475 | entrezgene:pubmed | pubmed-article:17292937 | lld:entrezgene |
| entrez-gene:17874 | entrezgene:pubmed | pubmed-article:17292937 | lld:entrezgene |
| entrez-gene:21898 | entrezgene:pubmed | pubmed-article:17292937 | lld:entrezgene |
| entrez-gene:106759 | entrezgene:pubmed | pubmed-article:17292937 | lld:entrezgene |
| entrez-gene:117149 | entrezgene:pubmed | pubmed-article:17292937 | lld:entrezgene |
| entrez-gene:225471 | entrezgene:pubmed | pubmed-article:17292937 | lld:entrezgene |
| entrez-gene:1489834 | entrezgene:pubmed | pubmed-article:17292937 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17292937 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17292937 | lld:pubmed |
