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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-5-8
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pubmed:abstractText |
We have previously shown that mutations of CD14 or TLR4 impair type I interferon (IFN) production and macrophage survival during infection with vesicular stomatitis virus (VSV). We now report that VSV glycoprotein G (gpG) is essential for the induction of a previously unrecognized CD14/TLR4-dependent response pathway in which the adapter TRAM has predominant importance, absent any need for MyD88 or Mal, and with only a partial requirement for TRIF. Downstream of TRAM, IRF7 activation leads to a type I IFN response. The pathway is utilized by myeloid dendritic cells (mDCs) and macrophages rather than plasmacytoid DCs. This new mode of TLR4 signal transduction, which does not stimulate NF-kappaB activation, reveals the importance of viral protein recognition by mDCs and shows that TLR4 can drive qualitatively different events within the cell in response to different ligands.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Vesicular...,
http://linkedlifedata.com/resource/pubmed/chemical/G protein, vesicular stomatitis...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-7,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Irf7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/MAL protein, T-cell,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myd88 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/Proteolipids,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/TICAM-1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/TIRP protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tlr4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0042-6822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
362
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
304-13
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17292937-Adaptor Proteins, Vesicular Transport,
pubmed-meshheading:17292937-Animals,
pubmed-meshheading:17292937-Cell Line,
pubmed-meshheading:17292937-Cell Survival,
pubmed-meshheading:17292937-Dendritic Cells,
pubmed-meshheading:17292937-Female,
pubmed-meshheading:17292937-Gene Expression Regulation,
pubmed-meshheading:17292937-Humans,
pubmed-meshheading:17292937-Interferon Regulatory Factor-7,
pubmed-meshheading:17292937-Interferon Type I,
pubmed-meshheading:17292937-Macrophages, Peritoneal,
pubmed-meshheading:17292937-Male,
pubmed-meshheading:17292937-Membrane Glycoproteins,
pubmed-meshheading:17292937-Membrane Transport Proteins,
pubmed-meshheading:17292937-Mice,
pubmed-meshheading:17292937-Mice, Inbred C57BL,
pubmed-meshheading:17292937-Mice, Knockout,
pubmed-meshheading:17292937-Models, Animal,
pubmed-meshheading:17292937-Myelin Proteins,
pubmed-meshheading:17292937-Myeloid Differentiation Factor 88,
pubmed-meshheading:17292937-Proteolipids,
pubmed-meshheading:17292937-RNA, Messenger,
pubmed-meshheading:17292937-Receptors, Interleukin,
pubmed-meshheading:17292937-Signal Transduction,
pubmed-meshheading:17292937-Toll-Like Receptor 4,
pubmed-meshheading:17292937-Vesicular stomatitis Indiana virus,
pubmed-meshheading:17292937-Viral Envelope Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.
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pubmed:affiliation |
Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA. philippe.georgel@hemato-ulp.u-strasbg.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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