Linked Life Data

17292870

Source:http://linkedlifedata.com/resource/pubmed/id/17292870

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-3-5
pubmed:abstractText
The lateral tuberal nucleus (LTN) is a hypothalamic region that has been identified with certainty only in humans and primates. It is composed of three small round globular units which protrude the basal surface of the brain along the optic tract. The function of the LTN is unknown. Recently, a tiny, parvalbumin-positive (PV1) nucleus was detected in the lateral hypothalamus of rodents. Like the human LTN, the rodent PV1-nucleus is subdivided into three units and lies along the optic tract. To ascertain whether the human LTN and the rodent PV1-nucleus could be considered as homologous structures not only based on their topographic location but also because of their neurochemical characteristics, we subjected tissue samples from humans, rats and mice to immunohistochemical analysis for a panel of neural markers. The human LTN was intensely immunoreactive for somatostatin and FF1, but only weakly so or not at all for parvalbumin, calbindin and calretinin. The rodent PV1-nucleus was intensely immunoreactive for parvalbumin but was not immunoreactive for either somatostatin, a surrogate for human FF1, calbindin or calretinin. Hence, using these neural markers, it was not possible to demonstrate a neurochemical homology between the human LTN and the rodent PV1-nucleus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
1139
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
110-6
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The human lateral tuberal nucleus: Immunohistochemical characterization and analogy to the rodent PV1-nucleus.
pubmed:affiliation
Anatomy Unit, University of Fribourg, Rte Albert Gockel 1, CH-1700 Fribourg, Switzerland. ankhemet@bluemail.ch
pubmed:publicationType
Journal Article, Comparative Study