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rdf:type |
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lifeskim:mentions |
umls-concept:C0019163,
umls-concept:C0019167,
umls-concept:C0039194,
umls-concept:C0205178,
umls-concept:C0205217,
umls-concept:C0444669,
umls-concept:C0524909,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1992-2-10
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pubmed:abstractText |
T cell proliferative responses to hepatitis B virus-encoded envelope antigen (S + preS2 + preS1), recombinant core antigen (HBcAg), and natural hepatitis B e antigen (HBeAg) were examined in 22 HBeAg-positive patients with chronic type B hepatitis and 17 healthy hepatitis B surface antigen (HBsAg) carriers. The results showed that HBeAg-positive patients had (a) higher levels of T cell responses to HBcAg/HBeAg than those of healthy HBsAg carriers (P less than 0.001 and P less than 0.01, respectively); (b) a further increase in these T cell responses during acute exacerbations (P less than 0.05 and P less than 0.05, respectively); (c) subsidence in the T cell responses to HBcAg/HBeAg after recovery from acute exacerbations and HBeAg seroconversion, whereas the responses would persist at high levels if the patients did not enter a clinical remission; and (d) low levels of T cell responses to S + preS2 + preS1 either before or after HBeAg seroconversion. The appearance of increasing T cell responses to HBcAg/HBeAg usually occurred in the early phase of acute exacerbations. These findings imply that HBcAg/HBeAg-specific T cells play an important role in the exacerbations of chronic hepatitis B and in HBeAg seroconversion. HBcAg/HBeAg-specific precursor T cell frequencies were serially studied in selected cases by limiting dilution assay. Elevation (two- to fourfold) of HBcAg/HBeAg-specific precursor T cell frequencies contributed to the increase of HBcAg/HBeAg-specific T cell proliferation during acute exacerbations.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-1085784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-1827917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-1832237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2195346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2210669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2230128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2258161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2365197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2394332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2395863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2431106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2439590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2440947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2460543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2570285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2671579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-2957446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-3038725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-3301618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-3354197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-3514406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-3701304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-3794299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-3997072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-4346033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-5637478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-6118576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-6189903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-6618432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-6690350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-6848416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-7009746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-7441214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1729285-78902
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
87-96
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1729285-Adult,
pubmed-meshheading:1729285-Base Sequence,
pubmed-meshheading:1729285-Female,
pubmed-meshheading:1729285-Follow-Up Studies,
pubmed-meshheading:1729285-Hepatitis, Chronic,
pubmed-meshheading:1729285-Hepatitis B,
pubmed-meshheading:1729285-Hepatitis B Core Antigens,
pubmed-meshheading:1729285-Hepatitis B e Antigens,
pubmed-meshheading:1729285-Humans,
pubmed-meshheading:1729285-Immune Tolerance,
pubmed-meshheading:1729285-Lymphocyte Activation,
pubmed-meshheading:1729285-Male,
pubmed-meshheading:1729285-Molecular Sequence Data,
pubmed-meshheading:1729285-Prospective Studies,
pubmed-meshheading:1729285-T-Lymphocytes,
pubmed-meshheading:1729285-Time Factors
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pubmed:year |
1992
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pubmed:articleTitle |
Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion.
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pubmed:affiliation |
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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