Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-2-12
pubmed:abstractText
Expanded polytetrafluoroethylene (ePTFE) was chemically modified to retard the growth of Staphylococcus aureus bacteria. This was accomplished by microwave plasma reactions in the presence of maleic anhydride (MA) to create acid functional groups on ePTFE surfaces, followed by esterification reactions with 200 and 600 molecular weight linear polyethylene glycol (PEG). Such surfaces were utilized for further reactions with penicillin (PEN) through etherification reactions to create anti-microbial surfaces. These reactions resulted in surface morphological changes, and spectroscopic analysis using attenuated total reflectance Fourier transform infrared spectroscopy (ATR FT-IR) revealed the formation of ester linkages resulting from reactions between PEN and PEG functionalities. Antibacterial activities were evaluated by a series of experiments where PEN-modified ePTFE specimens were immersed in a liquid aureus culture, and the bacteria growth was quantified by measuring % absorbance of the suspension at 600 nm wavelength. The lowest absorbance was observed for the solution containing PEN-PEG-MA-ePTFE specimens, thus showing highly effective anti-bacterial activity toward gram-positive Staphylococcus aureus bacteria. To our best knowledge, this is the first study that shows PEN-ePTFE surface modifications that are effective against gram-positive aureus bacteria.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1525-7797
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
713-8
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Antibacterial surfaces on expanded polytetrafluoroethylene; penicillin attachment.
pubmed:affiliation
School of Polymers and High Performance Materials, Shelby F. Thames Polymer Science Research Center, The University of Southern Mississippi, Hattiesburg, Mississippi 39406, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.