Source:http://linkedlifedata.com/resource/pubmed/id/17290351
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2007-2-9
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| pubmed:abstractText |
The RAS protooncogene has an important, although not yet established role in thyroid neoplasia. In this study, we evaluated the H-RAS mRNA and protein levels in human samples of nontoxic and toxic multinodular goiter samples, according to serum TSH levels. The mean of H-RAS mRNA levels in nodules of nontoxic nodular goiter were significantly increased compared to nonnodular tissue (1.49+/-1.21 vs. 0.94+/-0.81 AU, P=0.016). Nine of the 18 specimens (50%) of nontoxic multinodular goiter exhibited increased levels of H-RAS mRNA. The increased H-RAS mRNA levels were paralleled by inRAcreased H-Ras protein levels in about 90% of the cases. Interestingly, no differences were observed in H-RAS expression between nodules and adjacent nonnodular tissue in toxic nodular goiters (0.58+/-0.27 vs. 0.58+/-0.20 AU, P=0.88). None of the 10 samples from toxic multinodular goiters exhibited overexpression of H-RAS. The H-RAS expression was positively correlated with thyroglobulin expression (r2=0.51; P=0.04). In conclusion, we demonstrated increased levels of H-RAS mRNA and protein in samples of nontoxic multinodular goiter, indicating that it might be involved in goiter pathogenesis. In contrast, H-RAS overexpression was not detected in any of the samples of toxic multinodular goiter, suggesting different mechanisms for cell proliferation in nodular goiter according to thyroid status.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1699-5848
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
409-16
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| pubmed:meshHeading |
pubmed-meshheading:17290351-Adult,
pubmed-meshheading:17290351-Aged,
pubmed-meshheading:17290351-Cell Proliferation,
pubmed-meshheading:17290351-DNA Mutational Analysis,
pubmed-meshheading:17290351-Female,
pubmed-meshheading:17290351-Gene Expression,
pubmed-meshheading:17290351-Genes, ras,
pubmed-meshheading:17290351-Goiter, Nodular,
pubmed-meshheading:17290351-Humans,
pubmed-meshheading:17290351-Male,
pubmed-meshheading:17290351-Middle Aged,
pubmed-meshheading:17290351-Oncogene Protein p21(ras),
pubmed-meshheading:17290351-RNA, Messenger,
pubmed-meshheading:17290351-Retrospective Studies,
pubmed-meshheading:17290351-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17290351-Thyroglobulin,
pubmed-meshheading:17290351-Thyrotoxicosis,
pubmed-meshheading:17290351-Thyrotropin
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| pubmed:year |
2007
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| pubmed:articleTitle |
H-RAS gene expression in human multinodular goiter.
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| pubmed:affiliation |
Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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