Tumor-infiltrating lymphocytes represent the host immune response to cancer. CD4+CD25+FOXP3+ regulatory T cells (Tregs) suppress the immune reaction. The aim of the present study was to investigate the clinicopathologic significance and roles of Tregs and CD8+ T cells during hepatocarcinogenesis.
Pathology Division, National Cancer Center Research Institute, National Cancer Center Hospital, Tokyo, and Gastroenterology Division, Yokohama City University Hospital, Yokohama, Japan.