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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2007-4-2
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pubmed:abstractText |
We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor gamma-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0264-410X
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pubmed:author |
pubmed-author:AsaiRitsukoR,
pubmed-author:AsakiRyokoR,
pubmed-author:ChenPei-JerPJ,
pubmed-author:FukamizuReikoR,
pubmed-author:HashimotoSatomiS,
pubmed-author:InoueRurikoR,
pubmed-author:IshidaIsaoI,
pubmed-author:KanamaruNorikoN,
pubmed-author:KaseTetsuoT,
pubmed-author:KitaYokoY,
pubmed-author:MorikawaShigeruS,
pubmed-author:NakataniHitoshiH,
pubmed-author:NamieYumiY,
pubmed-author:NishidaYasukoY,
pubmed-author:NomuraTatsujiT,
pubmed-author:OkadaMasajiM,
pubmed-author:OkunoYoshinobuY,
pubmed-author:PeirisJ S MJS,
pubmed-author:SakataniMitsunoriM,
pubmed-author:TakaoKyokoK,
pubmed-author:TakemotoYujiY,
pubmed-author:TashiroMasatoM,
pubmed-author:TsunaiYoshieY,
pubmed-author:YamadaJunkoJ,
pubmed-author:YamamotoNaokiN,
pubmed-author:YoshidaShigetoS
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pubmed:issnType |
Print
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pubmed:day |
20
|
|
pubmed:volume |
25
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
3038-40
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pubmed:meshHeading |
pubmed-meshheading:17289225-Animals,
pubmed-meshheading:17289225-Disease Models, Animal,
pubmed-meshheading:17289225-Immunization, Passive,
pubmed-meshheading:17289225-Immunotherapy,
pubmed-meshheading:17289225-Mice,
pubmed-meshheading:17289225-Mice, SCID,
pubmed-meshheading:17289225-SARS Virus,
pubmed-meshheading:17289225-Severe Acute Respiratory Syndrome,
pubmed-meshheading:17289225-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:17289225-Vaccines, DNA,
pubmed-meshheading:17289225-Viral Vaccines
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pubmed:year |
2007
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pubmed:articleTitle |
Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models.
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pubmed:affiliation |
Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku, Sakai, Osaka 591-8555, Japan. okm@kch.hosp.go.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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