Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1992-2-6
|
pubmed:abstractText |
The effect of prior antibiotic treatment on the course of otitis media was assessed in a group of 62 children who experienced 83 episodes of ear infection during 3 years of observation. Bacterial quantitation in middle ear fluids demonstrated a significantly higher colony count in symptomatic children (3.9 x 10(4) +/- 12 bacteria per milliliter) compared to asymptomatic children (6.3 x 10(3) +/- 10 bacteria per milliliter; p = .05). Bacterial counts similarly tended to be higher in children with Streptococcus pneumoniae (4.0 x 10(6) +/- 16 bacteria per milliliter) and Hemophilus influenzae (2.0 x 10(6) +/- 16 bacteria per milliliter), who were more often symptomatic (73% and 55%, respectively, versus 38%) than children with Moraxella catarrhalis (7.9 x 10(3) +/- 2). Antibiotic therapy between 3 and 30 days prior to bacterial diagnosis was associated with a reduction in symptoms from 70% to 38% (p less than .025). However, prior treatment did not statistically reduce bacterial colony counts, although S pneumoniae decreased 90% in the previously treated group. Resistance to ampicillin occurred in 0% of S pneumoniae, 39% of nontypeable H influenzae, and 80% of M catarrhalis subjects without prior treatment and in 0%, 46%, and 100%, respectively, of subjects previously treated (p less than .025). These data suggest that prior treatment has a significant impact on the subsequent course of otitis media in children.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0003-4894
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
101
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
87-91
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:1728891-Anti-Bacterial Agents,
pubmed-meshheading:1728891-Child, Preschool,
pubmed-meshheading:1728891-Colony Count, Microbial,
pubmed-meshheading:1728891-Female,
pubmed-meshheading:1728891-Haemophilus Infections,
pubmed-meshheading:1728891-Haemophilus influenzae,
pubmed-meshheading:1728891-Humans,
pubmed-meshheading:1728891-Infant,
pubmed-meshheading:1728891-Male,
pubmed-meshheading:1728891-Microbial Sensitivity Tests,
pubmed-meshheading:1728891-Moraxella (Branhamella) catarrhalis,
pubmed-meshheading:1728891-Neisseriaceae Infections,
pubmed-meshheading:1728891-Otitis Media,
pubmed-meshheading:1728891-Prospective Studies,
pubmed-meshheading:1728891-Streptococcal Infections,
pubmed-meshheading:1728891-Streptococcus pneumoniae
|
pubmed:year |
1992
|
pubmed:articleTitle |
Effect of prior antibiotic treatment on middle ear disease in children.
|
pubmed:affiliation |
Division of Infectious Diseases, State University of New York School of Medicine, Buffalo.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|