Linked Life Data

17287521

Source:http://linkedlifedata.com/resource/pubmed/id/17287521

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-2-8
pubmed:abstractText
Infant maternal separation, a paradigm of early life stress in rodents, elicits long-lasting changes in gene expression that persist into adulthood. In BALB/c mice, an inbred strain with spontaneously elevated anxiety and stress reactivity, infant maternal separation led to increased depression-like behavioral responses to adult stress and robustly increased editing of serotonin 2C receptor pre-mRNA. Chronic fluoxetine treatment of adult BALB/c mice exposed to early life stress affected neither their behavioral responses to stress nor their basal 5-HT2C pre-mRNA editing phenotype. However, when fluoxetine was administered during adolescence, depression-like behavioral responses to stress were significantly diminished in these mice, and their basal and stress-induced 5-HT2C pre-mRNA editing phenotypes were significantly lower. Moreover, when BALB/c mice exposed to early life stress were raised in an enriched postweaning environment, their depression-like behavioral responses to adult stress were also significantly diminished. However, their 5-HT2C pre-mRNA editing phenotype remained unaltered. Hence, the similar behavioral effects of enrichment and fluoxetine treatment during adolescence were not accompanied by similar changes in 5-HT2C pre-mRNA editing. Enriched and nonenriched BALB/c mice exposed to early life stress also exhibited significantly increased expression of mRNA and protein encoding the G alpha q subunit of G-protein that couples to 5-HT2A/2C receptors. In contrast, G alpha q expression levels were significantly lower in fluoxetine-treated mice. These findings suggest that compensatory changes in G alpha q expression occur in mice with persistently altered 5-HT2C pre-mRNA editing and provide an explanation for the dissociation between 5-HT2C receptor editing phenotypes and behavioral stress responses.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
7
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1467-73
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17287521-Age Factors, pubmed-meshheading:17287521-Animals, pubmed-meshheading:17287521-Anxiety, Separation, pubmed-meshheading:17287521-Body Weight, pubmed-meshheading:17287521-Depressive Disorder, pubmed-meshheading:17287521-Emotions, pubmed-meshheading:17287521-Environment, pubmed-meshheading:17287521-Female, pubmed-meshheading:17287521-Fluoxetine, pubmed-meshheading:17287521-GTP-Binding Protein alpha Subunits, Gq-G11, pubmed-meshheading:17287521-Genetic Predisposition to Disease, pubmed-meshheading:17287521-Helplessness, Learned, pubmed-meshheading:17287521-Male, pubmed-meshheading:17287521-Mice, pubmed-meshheading:17287521-Mice, Inbred BALB C, pubmed-meshheading:17287521-Mice, Inbred C57BL, pubmed-meshheading:17287521-Neocortex, pubmed-meshheading:17287521-Protein Isoforms, pubmed-meshheading:17287521-RNA Editing, pubmed-meshheading:17287521-RNA Precursors, pubmed-meshheading:17287521-Random Allocation, pubmed-meshheading:17287521-Receptor, Serotonin, 5-HT2C, pubmed-meshheading:17287521-Serotonin, pubmed-meshheading:17287521-Serotonin Uptake Inhibitors, pubmed-meshheading:17287521-Species Specificity, pubmed-meshheading:17287521-Swimming
pubmed:year
2007
pubmed:articleTitle
Early life stress alters adult serotonin 2C receptor pre-mRNA editing and expression of the alpha subunit of the heterotrimeric G-protein G q.
pubmed:affiliation
Department of Psychiatry, Columbia University, New York, New York 10032, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural