Source:http://linkedlifedata.com/resource/pubmed/id/17286431
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2007-2-23
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| pubmed:abstractText |
Two new monomeric and two new dimeric drimane sesquiterpenes, cinnamacrins A-C (1-3) and cinnafragrin D (4), along with bemadienolide (5), capsicodendrin (6), cinnamodial (7), cinnamolide (8), isopolygodial (9), and delta-tocotrienol (10), were isolated from Cinnamosma macrocarpa. The structures of the new compounds were determined by physical, chemical, and spectroscopic evidence. Capsicodendrin (6) and/or cinnamodial (7) are the major compounds in C. fragrans and C. macrocarpa, which are both widely used in Malagasy traditional medicine. The cytostatic activity as well as alpha-glucosidase inhibition and antiviral activities of the major constituents 6 and 7 and the compounds previously isolated from C. fragrans were evaluated.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0163-3864
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
70
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
277-82
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| pubmed:meshHeading |
pubmed-meshheading:17286431-Angiosperms,
pubmed-meshheading:17286431-Animals,
pubmed-meshheading:17286431-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:17286431-Crystallography, X-Ray,
pubmed-meshheading:17286431-Drug Screening Assays, Antitumor,
pubmed-meshheading:17286431-Enterovirus,
pubmed-meshheading:17286431-Humans,
pubmed-meshheading:17286431-Madagascar,
pubmed-meshheading:17286431-Medicine, Traditional,
pubmed-meshheading:17286431-Mice,
pubmed-meshheading:17286431-Molecular Conformation,
pubmed-meshheading:17286431-Molecular Structure,
pubmed-meshheading:17286431-Plants, Medicinal,
pubmed-meshheading:17286431-Respiratory Syncytial Viruses,
pubmed-meshheading:17286431-Sesquiterpenes,
pubmed-meshheading:17286431-Simplexvirus,
pubmed-meshheading:17286431-T-Lymphocytes,
pubmed-meshheading:17286431-Vaccinia virus,
pubmed-meshheading:17286431-alpha-Glucosidases
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Cinnamacrins A-C, cinnafragrin D, and cytostatic metabolites with alpha-glucosidase inhibitory activity from Cinnamosma macrocarpa.
|
| pubmed:affiliation |
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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