Linked Life Data

17286278

Source:http://linkedlifedata.com/resource/pubmed/id/17286278

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-2-22
pubmed:abstractText
We demonstrated previously that when hippocampal-dependent learning and plasticity are compromised by fornix lesions, behaviorally induced expression of the immediate early gene, Arc, is correspondingly low. The medial septum and the vertical diagonal band are major sources of subcortical afferents that innervate the hippocampus via the fornix. Here we assessed the specific contribution of cholinergic afferents from these regions to the impairments in spatial learning and behavioral induction of Arc transcription produced by fornix lesions. The immunotoxin, 192 IgG-saporin, was used to produce selective lesions of cholinergic cell bodies in the medial septum and vertical diagonal band. Rats were then trained on both cued and spatial delayed match-to-place tasks in a radial arm water maze. Animals with 192 IgG-saporin lesions learned both cue and place discrimination tasks in the water maze normally, and showed only a mild and transient impairment when switching from the cued to the spatial version of the task. Following behavioral testing, rats explored two novel environments sequentially in a setting known to induce Arc expression in hippocampal pyramidal neurons. In marked contrast to the effects of complete fornix transection, quantitative in situ autoradiography revealed no differences in Arc mRNA expression between sham and lesion animals in CA1, CA3 or stratum radiatum. The conclusion from these data is that cholinergic deafferentation alone cannot account for the spatial learning deficits or impaired behavioral induction of Arc transcription produced by fornix lesions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1050-9631
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
227-34
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:17286278-Acetylcholine, pubmed-meshheading:17286278-Animals, pubmed-meshheading:17286278-Antibodies, Monoclonal, pubmed-meshheading:17286278-Cholinergic Fibers, pubmed-meshheading:17286278-Cues, pubmed-meshheading:17286278-Cytoskeletal Proteins, pubmed-meshheading:17286278-Denervation, pubmed-meshheading:17286278-Discrimination Learning, pubmed-meshheading:17286278-Fornix, Brain, pubmed-meshheading:17286278-Hippocampus, pubmed-meshheading:17286278-Male, pubmed-meshheading:17286278-Maze Learning, pubmed-meshheading:17286278-Memory, pubmed-meshheading:17286278-Memory Disorders, pubmed-meshheading:17286278-N-Glycosyl Hydrolases, pubmed-meshheading:17286278-Nerve Tissue Proteins, pubmed-meshheading:17286278-Pyramidal Cells, pubmed-meshheading:17286278-RNA, Messenger, pubmed-meshheading:17286278-Rats, pubmed-meshheading:17286278-Rats, Long-Evans, pubmed-meshheading:17286278-Ribosome Inactivating Proteins, Type 1, pubmed-meshheading:17286278-Septal Nuclei
pubmed:year
2007
pubmed:articleTitle
Selective cholinergic depletion of the hippocampus spares both behaviorally induced Arc transcription and spatial learning and memory.
pubmed:affiliation
Fishberg Department of Neuroscience & Alfred B. and Gudrun J. Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural