Linked Life Data

17283655

Source:http://linkedlifedata.com/resource/pubmed/id/17283655

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2007-2-7
pubmed:abstractText
Three unknown impurities in racecadotril bulk drug at levels below 0.5% were detected by simple reverse phase isocratic high performance liquid chromatography (HPLC). Structures for these impurities were proposed by molecular ion information and their fragmentation pattern obtained by LC-MS and these impurities were confirmed by NMR spectroscopy. The impurities I, II and III were characterized as benzyl 2-methyl carboximido acetate, benzyl 2-phenyl ethyl carboximido acetate, and benzyl 2-(1-benzyl vinyl carboximido) acetate. These structures were further confirmed by co-injecting of synthetic standards of impurities with racecadotril. The mechanism of the formation of these process related impurities is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0031-7144
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
994-8
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Structural studies of racecadotril and its process impurities by NMR and mass spectroscopy.
pubmed:affiliation
Department of Analytical Research, Discovery Research, Dr. Reddy's Laboratories Ltd., Miyapur, Hyderabad, India.
pubmed:publicationType
Journal Article