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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-2-23
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pubmed:abstractText |
Dopamine (DA) D1 receptor (D1R) stimulation in prefrontal cortex (PFC) produces an 'inverted-U' dose-response, whereby either too little or too much D1R stimulation impairs spatial working memory. This response has been observed across species, including genetic linkages with human cognitive abilities, PFC activation states and DA synthesis. The cellular basis for the inverted U has long been sought, with in vitro intracellular recordings supporting a variety of potential mechanisms. The current study demonstrates that the D1R agonist inverted-U response can be observed in PFC neurons of behaving monkeys: low levels of D1R stimulation enhance spatial tuning by suppressing responses to nonpreferred directions, whereas high levels reduce delay-related firing for all directions, eroding tuning. These sculpting actions of D1R stimulation are mediated in monkeys and rats by cyclic AMP intracellular signaling. The evidence for an inverted U at the cellular level in behaving animals promises to bridge in vitro molecular analyses with human cognitive experience.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
376-84
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17277774-Action Potentials,
pubmed-meshheading:17277774-Analysis of Variance,
pubmed-meshheading:17277774-Animals,
pubmed-meshheading:17277774-Behavior, Animal,
pubmed-meshheading:17277774-Cyclic AMP,
pubmed-meshheading:17277774-Dopamine Agents,
pubmed-meshheading:17277774-Dose-Response Relationship, Drug,
pubmed-meshheading:17277774-Drug Interactions,
pubmed-meshheading:17277774-Iontophoresis,
pubmed-meshheading:17277774-Macaca mulatta,
pubmed-meshheading:17277774-Male,
pubmed-meshheading:17277774-Maze Learning,
pubmed-meshheading:17277774-Memory, Short-Term,
pubmed-meshheading:17277774-Neurons,
pubmed-meshheading:17277774-Neuropsychological Tests,
pubmed-meshheading:17277774-Prefrontal Cortex,
pubmed-meshheading:17277774-Rats,
pubmed-meshheading:17277774-Rats, Sprague-Dawley,
pubmed-meshheading:17277774-Receptors, Dopamine D1,
pubmed-meshheading:17277774-Sensitivity and Specificity,
pubmed-meshheading:17277774-Thionucleotides
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pubmed:year |
2007
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pubmed:articleTitle |
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory.
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pubmed:affiliation |
Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, Connecticut 06520-8001, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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