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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-2-5
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pubmed:abstractText |
The TAPR locus containing the TIM gene family is implicated in the development of atopic inflammation in mouse, and TIM-1 allelic variation has been associated with the incidence of atopy in human patient populations. In this study, we show that manipulation of the TIM-1 pathway influences airway inflammation and pathology. Anti-TIM-1 mAbs recognizing distinct epitopes differentially modulated OVA-induced lung inflammation in the mouse. The epitopes recognized by these Abs were mapped, revealing that mAbs to both the IgV and stalk domains of TIM-1 have therapeutic activity. Unexpectedly, mAbs recognizing unique epitopes spanning exon 4 of the mucin/stalk domains exacerbated immune responses. Using Ag recall response studies, we demonstrate that the TIM-1 pathway acts primarily by modulating the production of T(H)2 cytokines. Furthermore, ex vivo cellular experiments indicate that TIM-1 activity controls CD4(+) T cell activity. These studies validate the genetic hypothesis that the TIM-1 locus is linked to the development of atopic disease and suggest novel therapeutic strategies for targeting asthma and other atopic disorders.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:BaillyVéroniqueV,
pubmed-author:ChangWenjieW,
pubmed-author:DoblesMaxM,
pubmed-author:GodboutKevinK,
pubmed-author:LiZhifangZ,
pubmed-author:MajeauGerardG,
pubmed-author:McCoonPatriciaP,
pubmed-author:MiklaszStevenS,
pubmed-author:PabloLourdesL,
pubmed-author:RaoSambasivaS,
pubmed-author:RennardRachelR,
pubmed-author:RennertPaul DPD,
pubmed-author:ScottMartin LML,
pubmed-author:SizingIrene DID,
pubmed-author:TarilonteLeticiaL,
pubmed-author:WalshMeghanM,
pubmed-author:ZafariMohammadM
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
178
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2249-61
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pubmed:meshHeading |
pubmed-meshheading:17277130-Animals,
pubmed-meshheading:17277130-Antibodies, Monoclonal,
pubmed-meshheading:17277130-Asthma,
pubmed-meshheading:17277130-Cells, Cultured,
pubmed-meshheading:17277130-Cytokines,
pubmed-meshheading:17277130-Epitope Mapping,
pubmed-meshheading:17277130-Epitopes,
pubmed-meshheading:17277130-Female,
pubmed-meshheading:17277130-Humans,
pubmed-meshheading:17277130-Lung,
pubmed-meshheading:17277130-Membrane Proteins,
pubmed-meshheading:17277130-Mice,
pubmed-meshheading:17277130-Mice, Inbred BALB C,
pubmed-meshheading:17277130-Ovalbumin,
pubmed-meshheading:17277130-Pneumonia,
pubmed-meshheading:17277130-Protein Structure, Tertiary,
pubmed-meshheading:17277130-Quantitative Trait Loci,
pubmed-meshheading:17277130-Th2 Cells
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pubmed:year |
2007
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pubmed:articleTitle |
Epitope-dependent effect of anti-murine TIM-1 monoclonal antibodies on T cell activity and lung immune responses.
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pubmed:affiliation |
Biogen Idec Incorporated, Cambridge, MA 02142, USA.
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pubmed:publicationType |
Journal Article
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