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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-2-23
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pubmed:abstractText |
The alpha7 subtype of the neuronal nicotinic acetylcholine receptors (nAChRs) was targeted for the design of selective agonists deriving from the quinuclidine scaffold. Arylidene groups at the 3-position and N-methyl quinuclidine were found to be selective agonists with EC(50)s of 1.5 and 40 microM, respectively.
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pubmed:grant |
|
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pubmed:language |
eng
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|
pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Mar
|
|
pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
17
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1520-2
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pubmed:dateRevised |
2010-6-4
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pubmed:meshHeading |
pubmed-meshheading:17276680-Animals,
pubmed-meshheading:17276680-Humans,
pubmed-meshheading:17276680-Nicotinic Agonists,
pubmed-meshheading:17276680-Oocytes,
pubmed-meshheading:17276680-Quinuclidines,
pubmed-meshheading:17276680-RNA, Messenger,
pubmed-meshheading:17276680-Receptors, Nicotinic,
pubmed-meshheading:17276680-Structure-Activity Relationship,
pubmed-meshheading:17276680-Xenopus
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors.
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|
pubmed:affiliation |
Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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