Linked Life Data

17276559

Source:http://linkedlifedata.com/resource/pubmed/id/17276559

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2007-4-2
pubmed:abstractText
The intestinal epithelium is a complex system of highly specialised cells that provide digestive and absorptive functions as well as innate and adaptive immunity. Induction of an adaptive immune response in the intestine can occur through the interaction of antigen with M-cells that overlay the lymphoid aggregates of the intestine (Peyer's patches). This study demonstrated that specific common microbial pathogen-associated molecular patterns are recognised by pattern recognition receptors on the surface of the M-cells and this interaction initiates transcytosis through the M-cell of particulate antigen from the intestinal milieu to underlying antigen presenting cells within the Peyer's patch. The study has found that among the pattern recognition molecules that have a role in recognising bacterial components, the apical expression of alpha5beta1 integrin was important for the transcytotic function of M-cells. A proportion of intestinal enterocytes transform to an M-cell morphology in vitro, when cultured with Peyer's patch cells and our studies have demonstrated that CD4+ cells are integral for the development of M-cells in vitro.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0264-410X
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3204-9
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Receptor mediated targeting of M-cells.
pubmed:affiliation
Macrophage Research Group, The Canberra Hospital, Canberra, ACT, Australia.
pubmed:publicationType
Journal Article