| pubmed-article:17276357 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17276357 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:17276357 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:17276357 | lifeskim:mentions | umls-concept:C0005495 | lld:lifeskim |
| pubmed-article:17276357 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:17276357 | lifeskim:mentions | umls-concept:C1150593 | lld:lifeskim |
| pubmed-article:17276357 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17276357 | pubmed:dateCreated | 2007-2-5 | lld:pubmed |
| pubmed-article:17276357 | pubmed:abstractText | Recent studies have demonstrated a strong relationship between aging-associated reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin resistance. Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitochondrial biogenesis, we examined AMPK activity in young and old rats and found that acute stimulation of AMPK-alpha(2) activity by 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and exercise was blunted in skeletal muscle of old rats. Furthermore, mitochondrial biogenesis in response to chronic activation of AMPK with beta-guanidinopropionic acid (beta-GPA) feeding was also diminished in old rats. These results suggest that aging-associated reductions in AMPK activity may be an important contributing factor in the reduced mitochondrial function and dysregulated intracellular lipid metabolism associated with aging. | lld:pubmed |
| pubmed-article:17276357 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17276357 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17276357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17276357 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17276357 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17276357 | pubmed:issn | 1550-4131 | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:PypaertMarcM | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:ShulmanGerald... | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:LiuZhen-Xiang... | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:HardieD... | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:LuJuJ | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:BefroyDouglas... | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:YoungLawrence... | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:HawleySimon... | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:ZongHaihongH | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:MustardKirsty... | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:MorinoKatsuta... | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:DongJianyingJ | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:YuHannah JHJ | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:ReznickRichar... | lld:pubmed |
| pubmed-article:17276357 | pubmed:author | pubmed-author:MooreIrene... | lld:pubmed |
| pubmed-article:17276357 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17276357 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:17276357 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17276357 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17276357 | pubmed:pagination | 151-6 | lld:pubmed |
| pubmed-article:17276357 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:meshHeading | pubmed-meshheading:17276357... | lld:pubmed |
| pubmed-article:17276357 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17276357 | pubmed:articleTitle | Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. | lld:pubmed |
| pubmed-article:17276357 | pubmed:affiliation | Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA. | lld:pubmed |
| pubmed-article:17276357 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17276357 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17276357 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:78975 | entrezgene:pubmed | pubmed-article:17276357 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17276357 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17276357 | lld:pubmed |
