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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-2-5
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pubmed:abstractText |
Recent studies have demonstrated a strong relationship between aging-associated reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin resistance. Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitochondrial biogenesis, we examined AMPK activity in young and old rats and found that acute stimulation of AMPK-alpha(2) activity by 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and exercise was blunted in skeletal muscle of old rats. Furthermore, mitochondrial biogenesis in response to chronic activation of AMPK with beta-guanidinopropionic acid (beta-GPA) feeding was also diminished in old rats. These results suggest that aging-associated reductions in AMPK activity may be an important contributing factor in the reduced mitochondrial function and dysregulated intracellular lipid metabolism associated with aging.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-10562646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-10846039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-10909077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-11701451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-11997383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-12153572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-12163024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-12444247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-12558800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-12750520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-14511394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-14517248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-15889149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-16054041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-16340011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-8910387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-9029219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17276357-9435525
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AICA ribonucleotide,
http://linkedlifedata.com/resource/pubmed/chemical/AMP-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Aminoimidazole Carboxamide,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Propionic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Stk11 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/guanidinopropionic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1550-4131
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pubmed:author |
pubmed-author:BefroyDouglasD,
pubmed-author:DongJianyingJ,
pubmed-author:HardieD GrahameDG,
pubmed-author:HawleySimon ASA,
pubmed-author:LiuZhen-XiangZX,
pubmed-author:LuJuJ,
pubmed-author:MooreIrene KIK,
pubmed-author:MorinoKatsutaroK,
pubmed-author:MustardKirsty JKJ,
pubmed-author:PypaertMarcM,
pubmed-author:ReznickRichard MRM,
pubmed-author:ShulmanGerald IGI,
pubmed-author:YoungLawrence HLH,
pubmed-author:YuHannah JHJ,
pubmed-author:ZongHaihongH
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
151-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17276357-AMP-Activated Protein Kinases,
pubmed-meshheading:17276357-Aging,
pubmed-meshheading:17276357-Aminoimidazole Carboxamide,
pubmed-meshheading:17276357-Animals,
pubmed-meshheading:17276357-Guanidines,
pubmed-meshheading:17276357-Male,
pubmed-meshheading:17276357-Mitochondria,
pubmed-meshheading:17276357-Multienzyme Complexes,
pubmed-meshheading:17276357-Physical Conditioning, Animal,
pubmed-meshheading:17276357-Propionic Acids,
pubmed-meshheading:17276357-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17276357-Rats,
pubmed-meshheading:17276357-Rats, Inbred F344,
pubmed-meshheading:17276357-Ribonucleotides
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pubmed:year |
2007
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pubmed:articleTitle |
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis.
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pubmed:affiliation |
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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