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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2007-3-13
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pubmed:abstractText |
Amplification, overexpression, and elevated activation of Akt have been detected in many human malignancies making it an important target for cancer therapy. The Akt substrate-binding site offers a large number of potential interactions to an appropriately designed small molecule and can form the basis for the development of selective inhibitors. Here, we report the progression of GSK3beta substrate-mimetic inhibitors towards the development of a potent, small molecule substrate-mimetic inhibitor of Akt.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2068-73
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:17276059-Antineoplastic Agents,
pubmed-meshheading:17276059-Binding Sites,
pubmed-meshheading:17276059-Cell Line, Tumor,
pubmed-meshheading:17276059-Chemistry, Pharmaceutical,
pubmed-meshheading:17276059-Crystallography, X-Ray,
pubmed-meshheading:17276059-Drug Design,
pubmed-meshheading:17276059-Drug Screening Assays, Antitumor,
pubmed-meshheading:17276059-Enzyme Inhibitors,
pubmed-meshheading:17276059-Glycogen Synthase Kinase 3,
pubmed-meshheading:17276059-Humans,
pubmed-meshheading:17276059-Models, Chemical,
pubmed-meshheading:17276059-Neoplasms,
pubmed-meshheading:17276059-Peptides,
pubmed-meshheading:17276059-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17276059-Substrate Specificity
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pubmed:year |
2007
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pubmed:articleTitle |
Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics.
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pubmed:affiliation |
Department of Chemistry, Yale University, PO Box 208107, New Haven, CT 06520, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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