Linked Life Data

17275645

Source:http://linkedlifedata.com/resource/pubmed/id/17275645

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-2-5
pubmed:abstractText
Mannose-binding lectin (MBL) may be involved in the biologic cascade of events initiated by wear debris and bacterial infection around loosened total hip arthroplasties (THAs). Individual responses to such stimuli may be dictated by genetic variation caused by single nucleotide polymorphisms (SNPs). We performed a case-control study on 4 MBL SNPs using case patients (n = 91) with aseptic loosening or deep infection (n = 71). Control subjects (n = 150) had clinically and radiologically well-fixed THAs for more than 10 years. Frequency of the C allele (P = .001) and that of the genotype C/C (P = .004) for the -550 SNP were associated with aseptic failure. The codon 54 SNP G allele (P = .012) and G/G genotype (P = .027) frequencies were associated with aseptic failure as well. In the septic group, the frequency of the C allele (P = .01) and that of the genotype C/C (P = .05) for the -550 SNP were significant. Failure of THAs may be under genetic influence to candidate susceptibility genes such as MBL.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0883-5403
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-70
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Genetic susceptibility to total hip arthroplasty failure--positive association with mannose-binding lectin.
pubmed:affiliation
Center for Hip Surgery, Wrightington Hospital, Wigan, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't