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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-2-8
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pubmed:abstractText |
Activation of interferon regulatory factor (IRF)-3 and/or IRF-7 drives the expression of antiviral genes and the production of alpha/beta IFN, a hallmark of antiviral responses triggered by Toll-like receptors (TLR). Here we describe a novel antiviral signaling pathway operating in myeloid (m) dendritic cells (DC) and macrophages that does not require IRF-3 and/or IRF-7 but is driven by IRF-1. IRF-1 together with myeloid differentiation factor 88 (MyD88) or IL-1 receptor-associated kinase (IRAK)-1 triggered IFN-beta promoter activation. IRF-1 physically interacted with MyD88 and activation of mDC via TLR-9 induced IRF-1-dependent IFN-beta production paralleled by rapid transcriptional activation of IFN-stimulated genes. The NF-kappaB-dependent production of pro-inflammatory cytokines, however, was not influenced by IRF-1. TLR-9 signaling through this pathway conferred cellular antiviral resistance while IRF-1-deficient mice displayed enhanced susceptibility to viral infection. These results demonstrate that TLR-9 activation of mDC and macrophages contributes to antiviral immunity via IRF-1.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-2980
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pubmed:author |
pubmed-author:AdlerHeikoH,
pubmed-author:DrexlerIngoI,
pubmed-author:GuggemoosSimoneS,
pubmed-author:HaasTobiasT,
pubmed-author:HeitAntjeA,
pubmed-author:KrugAnneA,
pubmed-author:LangRolandR,
pubmed-author:MagesJörgJ,
pubmed-author:SchiemannMatthiasM,
pubmed-author:SchmitzFrankF,
pubmed-author:WagnerHermannH
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-27
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17273999-Animals,
pubmed-meshheading:17273999-Blotting, Western,
pubmed-meshheading:17273999-Dendritic Cells,
pubmed-meshheading:17273999-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17273999-Flow Cytometry,
pubmed-meshheading:17273999-Humans,
pubmed-meshheading:17273999-Interferon Regulatory Factor-1,
pubmed-meshheading:17273999-Interferon-beta,
pubmed-meshheading:17273999-Interleukin-1 Receptor-Associated Kinases,
pubmed-meshheading:17273999-Macrophage Activation,
pubmed-meshheading:17273999-Macrophages,
pubmed-meshheading:17273999-Mice,
pubmed-meshheading:17273999-Mice, Inbred C57BL,
pubmed-meshheading:17273999-Microscopy, Confocal,
pubmed-meshheading:17273999-Myeloid Differentiation Factor 88,
pubmed-meshheading:17273999-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:17273999-Promoter Regions, Genetic,
pubmed-meshheading:17273999-Signal Transduction,
pubmed-meshheading:17273999-Toll-Like Receptor 9,
pubmed-meshheading:17273999-Transfection,
pubmed-meshheading:17273999-Vaccinia
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pubmed:year |
2007
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pubmed:articleTitle |
Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells.
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pubmed:affiliation |
Institute for Medical Microbiology, Immunology and Hygiene, Munich, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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