Source:http://linkedlifedata.com/resource/pubmed/id/17273166
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2007-5-15
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| pubmed:abstractText |
Alopecia areata (AA) is an autoimmune disorder of the hair follicle characterized by inflammatory cell infiltrates around actively growing (anagen) hair follicles. Substance P (SP) plays a critical role in the cutaneous neuroimmune network and influences immune cell functions through the neurokinin-1 receptor (NK-1R). To better understand the role of SP as an immunomodulatory neuropeptide in AA, we studied its expression and effects on immune cells in a C3H/HeJ mouse model for AA. During early stages of AA development, the number of SP-immunoreactive nerve fibers in skin is increased, compared to non-affected mice. However, during advanced stages of AA, the number of SP-immunoreactive nerves and SP protein levels in skin are decreased, whereas the expression of the SP-degrading enzyme neutral endopeptidase (NEP) is increased, compared to control skin. In AA, NK-1R is expressed on CD8+ lymphocytes and macrophages accumulating around affected hair follicles. Additional SP supply to the skin of AA-affected mice leads to a significant increase of mast cell degranulation and to accelerated hair follicle regression (catagen), accompanied by an increase of CD8+ cells-expressing granzyme B. These data suggest that SP, NEP, and NK-1R serve as important regulators in the molecular signaling network modulating inflammatory response in autoimmune hair loss.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Granzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Gzmb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunologic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Neprilysin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurokinin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1523-1747
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| pubmed:author |
pubmed-author:BotchkarevVladimir AVA,
pubmed-author:Freyschmidt-PaulPiaP,
pubmed-author:MardaryevAndrei NAN,
pubmed-author:MaurerMarcusM,
pubmed-author:PetersEva M JEM,
pubmed-author:SharovAndrey AAA,
pubmed-author:SharovaTatyana YTY,
pubmed-author:SiebenhaarFrankF,
pubmed-author:SundbergJohn PJP,
pubmed-author:SyskaWolfgangW
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| pubmed:issnType |
Electronic
|
| pubmed:volume |
127
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1489-97
|
| pubmed:dateRevised |
2007-12-3
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| pubmed:meshHeading |
pubmed-meshheading:17273166-Alopecia Areata,
pubmed-meshheading:17273166-Animals,
pubmed-meshheading:17273166-Autoimmune Diseases,
pubmed-meshheading:17273166-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17273166-Cell Degranulation,
pubmed-meshheading:17273166-Disease Models, Animal,
pubmed-meshheading:17273166-Gene Expression,
pubmed-meshheading:17273166-Granzymes,
pubmed-meshheading:17273166-Hair Follicle,
pubmed-meshheading:17273166-Immunologic Factors,
pubmed-meshheading:17273166-Mast Cells,
pubmed-meshheading:17273166-Mice,
pubmed-meshheading:17273166-Mice, Inbred C3H,
pubmed-meshheading:17273166-Neprilysin,
pubmed-meshheading:17273166-Nerve Fibers,
pubmed-meshheading:17273166-Receptors, Neurokinin-1,
pubmed-meshheading:17273166-Signal Transduction,
pubmed-meshheading:17273166-Substance P
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| pubmed:year |
2007
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| pubmed:articleTitle |
Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata).
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| pubmed:affiliation |
Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|