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rdf:type |
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|
lifeskim:mentions |
umls-concept:C0001455,
umls-concept:C0010531,
umls-concept:C0013081,
umls-concept:C0017262,
umls-concept:C0035820,
umls-concept:C0185117,
umls-concept:C0221464,
umls-concept:C0225336,
umls-concept:C0530979,
umls-concept:C1171318,
umls-concept:C1522318,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C2911684
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pubmed:issue |
4
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|
pubmed:dateCreated |
2007-3-22
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|
pubmed:abstractText |
Bone morphogenetic protein 4 (BMP-4) is a transforming growth factor beta family member cytokine that exerts proinflammatory effects on the endothelium and is likely to play a role in atherogenesis. Recent studies suggested that atheroprotective levels of shear stress control endothelial BMP-4 expression; however, the underlying mechanisms remained unknown.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1524-4636
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
776-82
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17272757-Animals,
pubmed-meshheading:17272757-Arterioles,
pubmed-meshheading:17272757-Bone Morphogenetic Protein 4,
pubmed-meshheading:17272757-Bone Morphogenetic Proteins,
pubmed-meshheading:17272757-Cells, Cultured,
pubmed-meshheading:17272757-Coronary Vessels,
pubmed-meshheading:17272757-Cyclic AMP,
pubmed-meshheading:17272757-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:17272757-Down-Regulation,
pubmed-meshheading:17272757-Endothelial Cells,
pubmed-meshheading:17272757-Gene Expression Regulation,
pubmed-meshheading:17272757-Humans,
pubmed-meshheading:17272757-RNA, Messenger,
pubmed-meshheading:17272757-Rats,
pubmed-meshheading:17272757-Splanchnic Circulation,
pubmed-meshheading:17272757-Stress, Mechanical,
pubmed-meshheading:17272757-Transcription, Genetic
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pubmed:year |
2007
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pubmed:articleTitle |
Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathway.
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pubmed:affiliation |
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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