Source:http://linkedlifedata.com/resource/pubmed/id/17271111
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2007-2-2
|
| pubmed:abstractText |
In the present study, lidocaine relaxed, in a concentration-dependent manner, the contractions induced by either phenylephrine or a high concentration of KCl (60 mM) in endothelium-intact rat aortic rings. Mechanical removal of endothelium did not significantly modify lidocaine-induced vasorelaxation. In endothelium-denuded aortic rings depolarized by 60 mM KCl, lidocaine inhibited Ca2+-induced contraction. Lidocaine also reduced the transient contraction elicited by phenylephrine in Ca2+-free medium. Pretreatment of endothelium-denuded aorta nonspecific K+ with tetraethylammonium, a channel blocker, had no effect on the relaxant effect of lidocaine. These results indicate that lidocaine induces an endothelium-independent relaxation in rat aortic rings. The main mechanisms may include suppression in Ca2+ through the voltage-sensitive Ca2+ influx intracellular Ca2+ channels and inhibition of release in the vascular smooth muscle cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:issn |
1557-170X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3753-6
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Endothelium-independent vasorelaxant effect of lidocaine in rat aortic rings.
|
| pubmed:affiliation |
Department of Physiology, Zhejiang University School of Medicine, Hangzhou 310031, P. R. China.
|
| pubmed:publicationType |
Journal Article
|