Source:http://linkedlifedata.com/resource/pubmed/id/17270735
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2007-2-2
|
| pubmed:abstractText |
The canonical Wnt-beta-catenin signaling pathway is important for a variety of developmental phenomena as well as for carcinogenesis. Here, we show that, in hippocampal neurons, NMDA-receptor-dependent activation of calpain induced the cleavage of beta-catenin at the N terminus, generating stable, truncated forms. These beta-catenin fragments accumulated in the nucleus and induced Tcf/Lef-dependent gene transcription. We identified Fosl1, one of the immediate-early genes, as a target of this signaling pathway. In addition, exploratory behavior by mice resulted in a similar cleavage of beta-catenin, as well as activation of the Tcf signaling pathway, in hippocampal neurons. Both beta-catenin cleavage and Tcf-dependent gene transcription were suppressed by calpain inhibitors. These findings reveal another pathway for beta-catenin-dependent signaling, in addition to the canonical Wnt-beta-catenin pathway, and suggest that this other pathway could play an important role in activity-dependent gene expression.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0896-6273
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
387-97
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:17270735-Amino Acid Sequence,
pubmed-meshheading:17270735-Animals,
pubmed-meshheading:17270735-Blotting, Western,
pubmed-meshheading:17270735-Calpain,
pubmed-meshheading:17270735-Cells, Cultured,
pubmed-meshheading:17270735-Gene Expression,
pubmed-meshheading:17270735-Glycogen Synthase Kinase 3,
pubmed-meshheading:17270735-Hippocampus,
pubmed-meshheading:17270735-Immunoprecipitation,
pubmed-meshheading:17270735-Mice,
pubmed-meshheading:17270735-Mice, Transgenic,
pubmed-meshheading:17270735-Molecular Sequence Data,
pubmed-meshheading:17270735-Neurons,
pubmed-meshheading:17270735-Plasmids,
pubmed-meshheading:17270735-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:17270735-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17270735-Transcription, Genetic,
pubmed-meshheading:17270735-Translocation, Genetic,
pubmed-meshheading:17270735-beta Catenin
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression.
|
| pubmed:affiliation |
Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|