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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2007-3-13
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pubmed:abstractText |
Monoglucosyl and monogalactosyl diglycerides (MGDGs) with medium-long length acyl chains, identified as active components in Euphorbiaceae, were synthesized. They were examined for antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. MGDGs with two octanoyl groups at both 1- and 2-positions showed the most potent activity. The stereoselectivity of pancreatic lipase was investigated in vitro where the preference for the 1 position in MGDGs is strictly related to the length of the acyl chains.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1971-8
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pubmed:meshHeading |
pubmed-meshheading:17270436-Animals,
pubmed-meshheading:17270436-Anti-Infective Agents,
pubmed-meshheading:17270436-Antifungal Agents,
pubmed-meshheading:17270436-Chemistry, Pharmaceutical,
pubmed-meshheading:17270436-Diglycerides,
pubmed-meshheading:17270436-Drug Design,
pubmed-meshheading:17270436-Fatty Acids,
pubmed-meshheading:17270436-Hydrolysis,
pubmed-meshheading:17270436-Lipase,
pubmed-meshheading:17270436-Models, Chemical,
pubmed-meshheading:17270436-Molecular Conformation,
pubmed-meshheading:17270436-Mucor,
pubmed-meshheading:17270436-Pancreas,
pubmed-meshheading:17270436-Pseudomonas,
pubmed-meshheading:17270436-Temperature
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pubmed:year |
2007
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pubmed:articleTitle |
Chemoenzymatic synthesis and in vitro studies on the hydrolysis of antimicrobial monoglycosyl diglycerides by pancreatic lipase.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, University of Trieste, P.zle Europa 1, 34127 Trieste, Italy. cateni@univ.trieste.it
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pubmed:publicationType |
Journal Article
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