Linked Life Data

17268851

Source:http://linkedlifedata.com/resource/pubmed/id/17268851

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-6-1
pubmed:abstractText
The biological implication of protein tyrosine nitration in signaling pathways triggered by nitric oxide is recently emerging. Here we report for the first time that nitrotyrosination occurs in the neural intermediate filament protein peripherin. In neuron-like PC12 cells, nitrated peripherin is associated with the cytoskeleton fraction, its level increases during the progression of NGF-induced differentiation and the nitrated protein remains closely associated with stable microtubules. Tyr 17 and Tyr 376 were identified by MALDI-TOF analyses as two specific residues endogenously nitrated. Finally, peripherin nitration is not restricted to PC12 cells but it is also present in vivo in rat brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0364-3190
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
433-41
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Tyrosine nitration is a novel post-translational modification occurring on the neural intermediate filament protein peripherin.
pubmed:affiliation
Section of Biochemistry, University of Milano, Via Celoria 10, 20100 Milano, Italy. gabriella.tedeschi@unimi.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't