Source:http://linkedlifedata.com/resource/pubmed/id/17267764
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2007-3-30
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pubmed:abstractText |
Thromboxane A(2) (TxA(2)) is assumed to contribute to the development of diabetes complications, including nephropathy. We investigated whether the selective thromboxane-prostanoid endoperoxide receptor antagonist, S18886, ameliorates renal damage in uninephrectomized (UNX) obese Zucker rats (OZR). S18886, at doses of 10 (S18886-10) and 30 (S18886-30) mg x kg(-1) x day(-1), was administered to UNX-OZR by gavage over 8 weeks (n = 8 each group). UNX lean rats (n = 12) and OZR rats that received placebo (OZR-PLAC, n = 8) served as controls. As compared with the OZR-PLAC, S18886 had no significant effect on the elevated blood pressure and the enhanced creatinine clearance, while augmented proteinuria was partially prevented (-12 and -37%, low and high dose, respectively; NS). The increased excretion of transforming growth factor beta(1) (TGF-beta(1)) and of the thromboxane metabolite 2,3-dinor thromboxane B(2) (TxB(2)) was lowered (P < 0.05). S18886 prevented both the enhanced mesangiolysis (P < 0.01) in the OZR-PLAC as well as enlargement and degeneration of podocytes. In the blood, S18886-30 augmented the antioxidant enzymes (P < 0.01) and lessened the increase of plasma advanced oxidation protein products (-25%, NS). Body weight, hyperglycemia, and dyslipidemia remained uninfluenced under both doses of treatment. S18886 has renoprotective properties in the model of UNX-OZR. It prevents mesangiolysis, reduces urinary TGF-beta(1) and 2,3-dinor-TxB(2) excretion, and enhances the antioxidative defense.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0012-1797
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
968-74
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pubmed:meshHeading |
pubmed-meshheading:17267764-Animals,
pubmed-meshheading:17267764-Blood Pressure,
pubmed-meshheading:17267764-Body Weight,
pubmed-meshheading:17267764-Capillaries,
pubmed-meshheading:17267764-Diabetes Mellitus, Type 2,
pubmed-meshheading:17267764-Diabetic Nephropathies,
pubmed-meshheading:17267764-Disease Models, Animal,
pubmed-meshheading:17267764-Kidney Glomerulus,
pubmed-meshheading:17267764-Male,
pubmed-meshheading:17267764-Naphthalenes,
pubmed-meshheading:17267764-Nephrectomy,
pubmed-meshheading:17267764-Organ Size,
pubmed-meshheading:17267764-Propionic Acids,
pubmed-meshheading:17267764-Rats,
pubmed-meshheading:17267764-Receptors, Thromboxane,
pubmed-meshheading:17267764-Renal Circulation
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pubmed:year |
2007
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pubmed:articleTitle |
Renal effects of S18886 (Terutroban), a TP receptor antagonist, in an experimental model of type 2 diabetes.
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pubmed:affiliation |
Slovak Medical University, Department of Clinical and Experimental Pharmacotherapy, Limbová 12, 83303 Bratislava, Slovakia. katarina.sebekova@szu.sk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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