17267413

Source:http://linkedlifedata.com/resource/pubmed/id/17267413

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0012854, umls-concept:C0076582, umls-concept:C0220781, umls-concept:C0243126, umls-concept:C1707689, umls-concept:C1883254
pubmed:issue	4
pubmed:dateCreated	2007-3-29
pubmed:abstractText	The boronic acid moiety is a versatile functional group useful in carbohydrate recognition, glycoprotein pull-down, inhibition of hydrolytic enzymes and boron neutron capture therapy. The incorporation of the boronic-acid group into DNA could lead to molecules of various biological functions. We have successfully synthesized a boronic acid-labeled thymidine triphosphate (B-TTP) linked through a 14-atom tether and effectively incorporated it into DNA by enzymatic polymerization. The synthesis was achieved using the Huisgen cycloaddition as the key reaction. We have demonstrated that DNA polymerase can effectively recognize the boronic acid-labeled DNA as the template for DNA polymerization, that allows PCR amplification of boronic acid-labeled DNA. DNA polymerase recognitions of the B-TTP as a substrate and the boronic acid-labeled DNA as a template are critical issues for the development of DNA-based lectin mimics via in vitro selection.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AI058051, http://linkedlifedata.com/resource/pubmed/grant/CA113917, http://linkedlifedata.com/resource/pubmed/grant/CA123329, http://linkedlifedata.com/resource/pubmed/grant/CA88343, http://linkedlifedata.com/resource/pubmed/grant/N01-CO-27184
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0411011
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Aptamers, Nucleotide, http://linkedlifedata.com/resource/pubmed/chemical/Boron Compounds, http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Directed DNA Polymerase, http://linkedlifedata.com/resource/pubmed/chemical/Thymine Nucleotides
pubmed:status	MEDLINE
pubmed:issn	1362-4962
pubmed:author	pubmed-author:AltierCraigC, pubmed-author:CarrascoNicolasN, pubmed-author:Caton-WilliamsJulianneJ, pubmed-author:FangHaoH, pubmed-author:HuangZhenZ, pubmed-author:JohnstonLynetteL, pubmed-author:KuoZ FZF, pubmed-author:LiMinyongM, pubmed-author:LinNaN, pubmed-author:SuyemotoMitsuM, pubmed-author:WangBingheB, pubmed-author:WangQianQ, pubmed-author:WangSimingS
pubmed:issnType	Electronic
pubmed:volume	35
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1222-9
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:17267413-Aptamers, Nucleotide, pubmed-meshheading:17267413-Boron Compounds, pubmed-meshheading:17267413-DNA, pubmed-meshheading:17267413-DNA Primers, pubmed-meshheading:17267413-DNA-Directed DNA Polymerase, pubmed-meshheading:17267413-Polymerase Chain Reaction, pubmed-meshheading:17267413-Spectrometry, Mass, Matrix-Assisted Laser..., pubmed-meshheading:17267413-Templates, Genetic, pubmed-meshheading:17267413-Thymine Nucleotides
pubmed:year	2007
pubmed:articleTitle	Design and synthesis of boronic-acid-labeled thymidine triphosphate for incorporation into DNA.
pubmed:affiliation	Department of Chemistry and Center for Biotechnology and Drug Design, Campus Box 4098, Georgia State University, Atlanta, GA 30302-4098, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural