Source:http://linkedlifedata.com/resource/pubmed/id/17265786
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2007-2-1
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| pubmed:abstractText |
Interleukin-1 (IL-1) beta is a putative mediator of the cancer anorexia/weight loss syndrome, and certain polymorphisms of its gene are thought to be associated with a greater risk of gastric cancer. Do these IL-1 beta genetic polymorphisms predispose patients with gastric and gastroesophageal cancer to the anorexia/weight loss syndrome? This study focused on 44 patients with metastatic gastric and gastroesophageal cancer. All underwent genotyping, completed serial quality-of-life questionnaires germane to appetite, and underwent meticulous serial follow-up. Patients with the IL-1 beta-31 C/T and T/T genotypes were more likely to describe a worse appetite at baseline than were those with the C/C genotype. In addition, patients with the IL-1 beta+3954 C/T and T/T genotypes showed greater improvements in their weight (P = 0.02) and in survival (hazard ratio, 0.3; P = 0.04) over time than did patients with the C/C genotype. These associations occurred independently of tumor response. These preliminary data suggest that certain interleukin-1 beta genetic polymorphisms may modulate the cancer anorexia/weight loss syndrome in patients with metastatic gastric and esophageal cancer. Confirmatory studies are warranted.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1544-6794
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| pubmed:author |
pubmed-author:CampbellMeganM,
pubmed-author:DakhilShaker RSR,
pubmed-author:FosterNathanN,
pubmed-author:JatoiAminahA,
pubmed-author:MailliardJames AJA,
pubmed-author:NguyenPhuong LPL,
pubmed-author:NikcevichDaniel ADA,
pubmed-author:StellaPhilip JPJ,
pubmed-author:SunDavidD,
pubmed-author:TschetterLoren KLK
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| pubmed:issnType |
Print
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| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
41-6
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| pubmed:meshHeading |
pubmed-meshheading:17265786-Adenocarcinoma,
pubmed-meshheading:17265786-Adult,
pubmed-meshheading:17265786-Aged,
pubmed-meshheading:17265786-Anorexia,
pubmed-meshheading:17265786-Esophagogastric Junction,
pubmed-meshheading:17265786-Female,
pubmed-meshheading:17265786-Genetic Predisposition to Disease,
pubmed-meshheading:17265786-Genotype,
pubmed-meshheading:17265786-Humans,
pubmed-meshheading:17265786-Interleukin-1beta,
pubmed-meshheading:17265786-Male,
pubmed-meshheading:17265786-Middle Aged,
pubmed-meshheading:17265786-Polymorphism, Genetic,
pubmed-meshheading:17265786-Prognosis,
pubmed-meshheading:17265786-Prospective Studies,
pubmed-meshheading:17265786-Quality of Life,
pubmed-meshheading:17265786-Stomach Neoplasms,
pubmed-meshheading:17265786-Survival Rate,
pubmed-meshheading:17265786-Syndrome,
pubmed-meshheading:17265786-Weight Loss
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Interleukin-1 genetic polymorphisms and their relationship to the cancer anorexia/weight loss syndrome in metastatic gastric and gastroesophageal junction adenocarcinoma.
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| pubmed:affiliation |
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA. jatoi.aminah@mayo.edu
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| pubmed:publicationType |
Journal Article
|