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rdf:type |
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lifeskim:mentions |
umls-concept:C0003864,
umls-concept:C0003873,
umls-concept:C0026336,
umls-concept:C0026339,
umls-concept:C0035804,
umls-concept:C0039103,
umls-concept:C0086418,
umls-concept:C0205314,
umls-concept:C0302350,
umls-concept:C0333348,
umls-concept:C0529330,
umls-concept:C0679622,
umls-concept:C0936012,
umls-concept:C1515655,
umls-concept:C1521840,
umls-concept:C2348480
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pubmed:issue |
2
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pubmed:dateCreated |
2007-2-22
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pubmed:abstractText |
Angiotensin II (Ang II) is known to have proinflammatory actions, and Ang II type 1 (AT(1)) receptors are up-regulated in the rheumatoid synovium, suggesting that this receptor could be a therapeutic target. The purpose of this study was to investigate the antiinflammatory potential of the selective AT(1) receptor antagonist losartan, which is currently used for the treatment of cardiovascular disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
441-7
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pubmed:dateRevised |
2007-8-13
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pubmed:meshHeading |
pubmed-meshheading:17265479-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:17265479-Animals,
pubmed-meshheading:17265479-Arthritis, Rheumatoid,
pubmed-meshheading:17265479-Carrageenan,
pubmed-meshheading:17265479-Disease Models, Animal,
pubmed-meshheading:17265479-Dose-Response Relationship, Drug,
pubmed-meshheading:17265479-Freund's Adjuvant,
pubmed-meshheading:17265479-Humans,
pubmed-meshheading:17265479-Losartan,
pubmed-meshheading:17265479-Male,
pubmed-meshheading:17265479-Rats,
pubmed-meshheading:17265479-Rats, Wistar,
pubmed-meshheading:17265479-Receptor, Angiotensin, Type 1,
pubmed-meshheading:17265479-Synovial Membrane,
pubmed-meshheading:17265479-Synovitis,
pubmed-meshheading:17265479-Tumor Necrosis Factor-alpha
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pubmed:year |
2007
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pubmed:articleTitle |
Angiotensin II type 1 receptor as a novel therapeutic target in rheumatoid arthritis: in vivo analyses in rodent models of arthritis and ex vivo analyses in human inflammatory synovitis.
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pubmed:affiliation |
University of Paisley, Paisley, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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