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pubmed-article:17264802pubmed:abstractTextIncreasing evidence suggests that a genetically determined functional impairment of the hepatocellular efflux transporters bile salt export pump (BSEP, ABCB11) and multidrug resistance protein 3 (MDR3, ABCB4) play a pathophysiological role in the development of drug-induced liver injury. The aim of this study was therefore to describe the extent of genetic variability in ABCB11 and ABCB4 in patients with drug-induced liver injury and to in vitro functionally characterize newly detected ABCB11 mutations and polymorphisms.lld:pubmed
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pubmed-article:17264802pubmed:articleTitleMutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury.lld:pubmed
pubmed-article:17264802pubmed:affiliationDivision of Clinical Pharmacology and Toxicology, University Hospital Zurich, Switzerland.lld:pubmed
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